... distantly related to the AAA+ and AP/NACHT NTPases [10,11,13] All eukaryotic and several bacterial members of the KAP family contain two or four transmembrane segments inserted into the P-loop NTPase ... [10] The ASCE division includes AAA+, ABC, PilT, superfamily 1/2 (SF1/2) helicases, and RecA/F1/F0 classes of ATPases, and a large assemblage of NTPases related to the AP(apoptotic) and NACHT families ... of the KAP family have a variable α-helical insert amino-terminal to the Walker B motif Remarkably, all animal KAP NTPases and three bacterial ones, those from Anabaena, G sulfurreducens and...