... length Vgf content in CSF in ALS In A, full-length Vgf was assessed by quantitative ELISA assays; in B, Vgf content decreased as a function of progression of muscle weakness assessed by manual muscle ... Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis BMC Neurosci 2006; 7: 29 Chakraborty ... precedes ALS-type muscle weakness in ~90 day-old symptomatic mutant G9 3A- SOD-1 mice and continue to decline as a function of progression of ALS-type clinical disease Values are expressed as mean ±...