Proteolytic and cellular mechanisms in prohormone and proprotein processing 1570595534

MOLECULAR AND CELLULAR MECHANISMS LEADING TO SIMILAR PHENOTYPES IN DOWN AND FETAL ALCOHOL SYNDROMES

MOLECULAR AND CELLULAR MECHANISMS LEADING TO SIMILAR PHENOTYPES IN DOWN AND FETAL ALCOHOL SYNDROMES
... University, August 2012 Molecular and Cellular Mechanisms Leading to Similar Phenotypes in Down and Fetal Alcohol Syndromes Major Professor: Randall J Roper Down syndrome (DS) and Fetal Alcohol Syndrome ... http://www.purdue.edu/policies/pages/teach_res_outreach/c_22.html MOLECULAR AND CELLULAR MECHANISMS LEADING TO SIMILAR PHENOTYPES IN DOWN AND FETAL ALCOHOL SYNDROMES A Thesis Submitted to the Faculty of Purdue University by Jeffrey Peter Solzak In Partial ... GRADUATE SCHOOL Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Molecular and Cellular Mechanisms Leading to Similar Phenotypes in Down and Fetal Alcohol Syndromes For the...
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Báo cáo khoa học: Peroxiredoxins as cellular guardians in Sulfolobus solfataricus – characterization of Bcp1, Bcp3 and Bcp4 pot

Báo cáo khoa học: Peroxiredoxins as cellular guardians in Sulfolobus solfataricus – characterization of Bcp1, Bcp3 and Bcp4 pot
... analysis of bcp1, bcp3 and bcp4 under oxidative stress The involvement of bcp1, bcp3 and bcp4 in oxidative stress was investigated by assessing mRNA levels following treatment of S solfataricus ... contrast, the Bcp3 sequence only shows one cysteine at position 42 in the N-terminal region Expression and purification of Bcp1, Bcp3 and Bcp4 bcp1, bcp3 and bcp4 were amplified by PCR from S solfataricus ... form of pUC19 are indicated on the left by arrows Temperature dependence and thermostability of Bcp1, Bcp3 and Bcp4 To characterize the thermophilicity of recombinant Bcp1, Bcp3 and Bcp4, we investigated...
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techniques and mechanisms in electrochemistry 1994 - hammett

techniques and mechanisms in electrochemistry 1994 - hammett
... Cataloging -in- Publication data Christensen, P.A., 1960– Techniques and mechanisms in electrochemistry / P.A Christensen and A Hamnett 1st ed p cm Includes bibliographical references and index ... references and index ISBN 0-7 51 4-0 12 9-3 (PB : acid-free) Electrochemistry Surface chemistry I Hamnett, A II Title QD553.C59 1993 541.3'7 dc20 9 3-1 1366 Techniques and Mechanisms in Electrochemistry by ... Techniques Giving Mechanistic Information 2.1—Surface Specific Processes -In Situ Techniques 2.1.1—Electrocapillarity 2.1.2—Linear Sweep Voltammetry and Cyclic Voltammetry 2.1.3—Scanning Tunnelling Microscopy...
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Báo cáo y học: "Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states." ppt

Báo cáo y học:
... HANDLED HANDLED 40 35 30 25 20 15 10 C A2 C A2 Figure Effects of handling on MR and GR immunoreactivity in the CA2 region of the hippocampus Effects of handling on MR and GR immunoreactivity ... assay system) Statistical Analysis Data were analyzed by a one-way analysis of variance (ANOVA) with handling as the independent factor Data on learning, body weight and food intake were analyzed ... consolidation of information) The effects of "neonatal handling" on cognition were accompanied by changes in GR and MR hippocampal levels: Higher GR and lower MR levels were found in the CA2 region of the...
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Báo cáo y học: "4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004" pot

Báo cáo y học:
... C5aR and FcgRIII-mediated cell activation resulting in innate cell mediator activation and the production of inflammatory cytokine interleukin-1 and TNF-α, leading to joint destruction In recent ... susceptibility genes By making use of adenovirus-based and cell-based transfers, the feasibility of novel therapeutic interventions will be capable of determination in future Competing interests ... chronic infection is based on the ability of the bacterium to escape complement-mediated opsonophago- cytosis by binding the complement inhibitor factor H (and in some cases, also the factor H-like...
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Báo cáo khoa học: "Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo" ppsx

Báo cáo khoa học:
... cell line is represented by four responses shown as two responses to fractionated doses (8 × Gy and × 5Gy) connected by dotted lines and two responses to single acute fractions (1 × 7.5 Gy and ... an increase in response in r compared to S and R responses Additionally, this response includes enhanced sensitivity to a single large fractions (15 Gy), a property shared with other cell lines ... group and both exhibit increased response to 15 Gy, but the relative response of the line abrogated in p21 results into increased sensitivity of this subline similar to the exaggerated response to...
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Báo cáo y học: "Profiling of cellular proteins in porcine reproductive and respiratory syndrome virus virions by proteomics analysis" pps

Báo cáo y học:
... cytoskeleton system proteins, which have the maximum profusion among the identified cellular proteins, including Actin, Keratin, Annexin, Coronin, Tubulin, Tropomyosin, and Cofilin Enveloped viruses ... Profiling of cellular proteins in porcine reproductive and respiratory syndrome virus virions by proteomics analysis Virology Journal 2010 7:242 Submit your next manuscript to BioMed Central and take ... Localization of actin in Moloney murine leukemia virus by immunoelectron microscopy Virology 1999, 260:23-34 39 Sasaki H, Nakamura M, Ohno T, Matsuda Y, Yuda Y, Nonomura Y: Myosinactin interaction plays...
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báo cáo khoa học: " Iron and ferritin accumulate in separate cellular locations in Phaseolus seeds" pdf

báo cáo khoa học:
... Nicotianamine (NA), citrate, and the iron transport protein (ITP) are responsible for binding iron in the xylem and phloem [12-14], while ferritins were suggested to store iron in legume seeds and ... amyloplasts remain unstained (Fig 5n and 5q) Ferritin accumulates in the amyloplasts of mature P coccineus seeds Ferritin has been suggested as the major iron- storing protein in legume seeds ... biofortification Ferritin accumulates in the amyloplasts of embryonic cells It has been suggested that phytoferritin-bound iron is the principal iron form during early germination [15] In peas, ferritin was...
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Báo cáo khoa học: " Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats" pptx

Báo cáo khoa học:
... to induce strong and specific humoral and cellular immune responses makes them potential candidates for designing a prophylactic and therapeutic vaccine against HCV Taken together the results of ... vaccination against hepatitis C virus (HCV): effect of expressing different forms of HCV E2 protein and use of CpGoptimized vectors in mice Vaccine 2002, 20:3263-3271 Lechmann M, Liang TJ: Vaccine ... reported in the HCV database within the NH2-terminal region of the HVR-1 of E2 protein The current peptides were selected to be genetically conserved at least among viral subtypes infecting the local...
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Báo cáo y học: "Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors" potx

Báo cáo y học:
... iron-containing haem proteins, including cytochromes and NADPH oxidases, were proposed some time ago as potential O2 sensors in a variety of cellular systems In NEBs, a number of lines of evidence point ... refers to ‘tandem of P-domains, weakly inward rectifying K2P channel’) — a member of the newly emerging gene family of voltageinsensitive tandem P-domain K+ (K2P) channels [28] Respiratory Research ... Chemotransduction in the carotid body: K+ current modulated by pO2 in type I chemoreceptor cells Science 1988, 241:580–582 Youngson C, Nurse C, Yeger H, Cutz E: Oxygen sensing in airway chemoreceptors...
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Báo cáo y học: "Homeostatic mechanisms in dopamine synthesis and release: a mathematical model" pptx

Báo cáo y học:
... L-3,4dihydroxyphenylalanine (l-dopa) by tyrosine hydroxylase (TH) and l-dopa is converted into cytosolic dopamine (cda) by aromatic amino acid decarboxylase (AADC) Cytosolic dopamine is transported into the ... understand the many homeostatic mechanisms involved in dopamine synthesis, release and reuptake We have demonstrated that substrate inhibition of tyrosine hydroxylase by tyrosine plays an important ... acronyms: vTyr, neutral amino acid transporter; DRR, dihydrobiopterin reductase; TH, tyrosine hydroxylase; AADC, aromatic amino acid decarboxylase; MAT, vesicular monoamine transporter; DAT, dopamine...
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PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1

PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
... was of interest to determine if endogenous SIMPL protein localizes to the nucleus in the presence of pro-inflammatory cytokines IL-1 and TNFα as well as the subcellular localization of SIMPL in ... SIMPL in the absence of cytokines Since the 087J antibody had been validated to be free of contaminating SIMPL protein and to be capable of detecting SIMPL in its native structure in immunoprecipitation ... LOCALIZATION IN RESPONSE TO TNF-α AND IL-1 SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB In response to pathogens, cytokines such as Interleukin-1 (IL-1) ...
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Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation body

Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation   body
... relation to learning and memory formation requirements Furthermore, the molecular mechanisms underlying the MFs redistribution during learning and memory formation are still under investigation ... hilus and CA3 area, comprise the second synapse of the hippocampal circuit In this trisynaptic model of the hippocampus, based on the observations of the MFs presynapses and their locations, the ... for the investigations on the learning- dependent morphological malleability, as well as the relations of synaptic plasticity with long-lasting memory The correlations between the basal size of the...
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