... 1. 2 Myristoylation was necessary for JSP1-induced activation of JNK 0.8 0.6 0.4 0.2 JSP1-wt JSP1-G2A JSP1-CS Fig JSP1 phosphatase activity was not dependent on myristoylation Recombinant JSP1-wt, ... regulator of the JNK signaling pathway [20, 21] Since myristoylation determined the subcellular localization of JSP1, we asked whether abrogation of myristoylation would also affect JSP1-induced JNK activation ... on the identification of physiological substrates of JSP1, to reveal the mechanism underlying its effects on JNK signaling and 2470 whether this is linked to the observed triggering of apoptosis...