... criticisms Importantly, they not address the effects of noradrenaline in vasodilated, hypotensive states and may not even accurately reflect the longer-term effect of noradrenaline infusion in normal ... is minimal 100 On the other hand, a study by Anderson and co-workers appears to mimic clinical practice more closely [18] These investigators infused noradrenaline intravenously at 0.2–0.4 µg/kg/minute ... interest is a study by Martin and co-workers because it is the only randomized, controlled study available [3] These investigators randomized 32 patients with hyperdynamic and hypotensive septic...