... process By identifying dysregulated genes in early and LS RA as compared with healthy synovia, we provide arguments that the biological processes, molecular functions, and pathways differed according ... pathway term in PANTHER A P value was determined using the binomial statistic (that is, the probability that the number of genes observed in each category occurred by chance [randomly], as determined ... and biological processes involved at RA onset Conversely, genes involved in the cell cycle, apoptosis inhibition, and granulocyte-mediated immunity were upregulated in LS RA, suggesting the involvement...