... determining immunity or immune tolerance; this determination is based on the maturation or activation state and the subset of DCs, and cytokine profiles in the microenvironment at the time of antigen ... = slight edema and erythema limited to the foot or ankle, = slight edema and erythema from the ankle to the tarsal bone, = moderate edema and erythema from the ankle to the tarsal bone, and = ... that are mediated by tryptophan depletion and by the production of metabolic byproducts collectively known as kynurenines [16,21,22] Demonstrating the concomitant induction of IDO enzymatic activity...