... experiments, for proteins with a tendency to aggregate at high concentrations, etc In the case of the T domain, the MG state corresponds to the functional state, which initiates the translocation of the ... catalytic domain Here, the data allowed identification of the core of the protein in the N state and the evolution of the overall structure of the protein in the MG state This degree of resolution ... During cell intoxication, diphtheria toxin is cleaved by furin into two fragments: the A chain corresponding to the catalytic domain (C domain) ; and the B chain corresponding to the translocation...