... doi:10.1186/1756-8722-3-40 Cite this article as: Usmani et al.: The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP9 0A and HSP90B1 Journal of Hematology & Oncology ... myeloma: results of a phase dose-escalation study Br J Haematol 150:438-445 Nakashima T, Ishii T, Tagaya H, Seike T, Nakagawa H, Kanda Y, Akinaga S, Soga S, Shiotsu Y: New molecular and biological ... evaluated the in vitro anti-myeloma activity of PU-H71, a novel purine scaffold HSP90 inhibitor We also determined if the anti-tumor activity of HSP90 inhibitors is achieved via targeting both...