... expression from the 1G promoter in the presence of increasing amounts of Fra1 may be due to the effects of Fra-1 on the proximal AP-1 site The greater increase in the induction of the 2G promoter may ... MMP-1 expression and may explain the decrease in protein binding to the AP-1/ 2G site Therefore, to determine which factors in the AP-1 or Ets family might be downregulated, we compared protein ... containing the 1G probe appear unchanged in the presence of the inhibitor (–) Thus, a decrease in the expression of MMP-1 in the presence of PD098059 may be due, at least in part, to a decrease in...