... linked to, but distinct from, apoptosis [9,10] Beclin 1, a class III phosphatidylinositol 3-kinaseinteracting protein [11], plays a role in promoting autophagy [12] Beclin contains a Bcl-2- binding ... response to nutrient deprivation Autophagy is strongly upregulated in response to nutrient deprivation [19,29] To examine the autophagic response to starvation in HL-1 cells, GFP–LC3expressing cells ... Beclin control of the autophagic response to nutrient deprivation requires a functional Bcl-2 ⁄ -XL-binding domain We next investigated the control of Beclin and its binding partner, Bcl-2, on autophagic...