... physician and founder of chemotherapy, developed an organic arsenical, Salvarsan (Arsphenamine), which was effective in treating tuberculosis and syphilis Arsphenamine was the standard therapy for ... (ROS) and depletion of glutathione [Park MJ et al., 2005] Induction of apoptosis through depolarization of mitochondrial membrane, activation of caspase-9, caspase-3 and PARP [Akao Y et al., 1999] ... mention of arsenicals was made by Hippocrates, who used realgar and orpiment pastes to treat ulcers Realgar is commonly used in traditional Chinese medicine (TCM) and available as pills, tablets, and...