... residing in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence of PTP in ... buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca2+]c, probably coincides with the cleavage of the exchanger (but see [164]) Therefore, inhibition of the, ... effective also in situ in this and other organs [100–103] The sensitivity of isolated brain mitochondria to cyclosporin A depends highly on the conditions: in the absence of adenine nucleotides and magnesium,...