... been found Aneuploidy has been described in 70% of CUP patients with metastatic adenocarcinoma or undifferentiated carcinoma The overexpression of various genes, including Ras, bcl-2 (40%), her-2 ... procedures may affect the choice of therapy and the patient's survival and quality of life The reason tumors present as CUP remains unclear One hypothesis is that the primary tumor either regresses ... hemogram, chest x-ray, CT scan of the abdomen and pelvis, mammography in women, and prostate-specific antigen (PSA) test in men With the increasing availability of additional sophisticated imaging...