... effects with those of the parentmolecule MDP. The results reported establish thesafety of MB, the absence of undesirable effects on thecentral nervous system, and the lack of induction of inflammatory ... absent followingtreatment with a non-toxic analogue such as murabutide. Stimulation of cells with MDP, but not with murabutide, rapidly upregulates the expres-sion of the mitochondrial protein ... is associated with upregulation of uncoupling protein 2 and the production of reactiveoxygen and reactive nitrogen speciesTakla G. El-Khoury, Georges M. Bahr and Karim S. EchtayFaculty of...