... hypoxia and reoxygenation have been reported to induce DNA damage [30–32], we examined the effects of pyruvate addition during hypoxia and after reoxygenation on DNA damage HepG2 cells were incubated ... by Singh et al [48], using alkaline electrophoresis, which allows detection of single-strand and double-strand breaks Pyruvate reduces DNA damage during...
... orders@intechweb.org Hepatocellular Carcinoma – Clinical Research, Edited by Wan-Yee Lau p cm ISBN 978-953-51-0112-3 Contents Preface IX Part Diagnosis / Differential Diagnosis Chapter Hepatocellular Carcinoma: ... Hepatocellular Carcinoma – Clinical Research Edited by Wan-Yee Lau Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright...
... implies that MYP has a role as a zinc transporter for gametogenesis In vertebrates, vitellogenin, a precursor of yolk protein, is a zinc- bind4994 ing protein that transports the zinc required for oogenesis ... as a substrate for localization of the labeled MYP Statistical analysis Data were expressed as the mean ± SEM Statistical analysis was...
... indicates that the location of HIP/PAP and RIIa is consistent with the relevance of their interaction HIP/PAP has been classified in the group of C-type lectins because it binds lactose and contains ... reticulum Ca2+ATPase (SERCA 2), an integral protein of the endoplasmic reticulum [22], calreticulin, a protein of the endoplasmic reticulum lumen [23], HI...
... glyoxalase pathway in Leishmania infantum A Fig Sensitivity analysis of the glyoxalase pathway in Leishmania infantum The effects of system parameters on the intracellular steady-state concentration ... 6C) The simulation results, based on experimentally determined parameters and a kinetic model of the 2393 The glyoxalase pathway in Leishma...
... limitation of the process is the identification of those antigens that are the most relevant as targets, as the human auto-antigen-specific T cell repertoire is diverse and the optimal antigen target ... Cite this article as: d’Hennezel et al.: IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in org...
... non-Hodgkin’s lymphoma as a single agent as well as in combination therapy, emphasizing its high B-cell-depleting potency [8] In patients with lymphoma, rituximab infusion is frequently associated ... by the US National Institutes of Health is in the planning stage 132 Although autoantibodies in autoimmune cytopenias and some other diseases, such as pemphigus and myastheni...
... GS: Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen -activated protein kinase kinase kinases in rheumatoid arthritis J Immunol 2004, 17 2 :16 12 -16 18 Huang Q, Yang J, Lin Y, Walker C, Cheng ... purposes) Arthritis Research & Therapy 10 11 12 13 14 15 16 17 18 19 20 21 Vol No Hammaker et al Mor A, Abramson SB, Pillinger MH: The fibroblast-like syno...
... strand, while the silencing activity of the siRNA was maintained [18] Polo-like kinase-1 (PLK-1) belongs to the family of serine/threonine kinases and regulates cell division in the mitotic phase ... the systemic siRNA delivery with atelocollagen existed intact for at least days in tumor tissues using a mouse model [62] Preclinical application of RNAi therapy against PLK-1 in a...
... of glioma 1. 4 Re-defining assay criteria for detecting GPCs 10 1. 5 PLK1 regulation and physiological role 11 1. 5 .1 PLK1 regulation 11 1. 5.2 Physiological role of PLK1 13 1. 5.3 PLK1 and tumors 15 ... 1. 9 34 3.3 PLK1 mRNA expression is elevated in glioma tumors PLK1 over-expression is common in several cancers of the breast 116 , ovaries 117 , prostate 118 and skin...
... (Polo- like kinase of X laevis); Snk (serum-inducible kinase) ; Fnk (fibroblastgrowth-factor-indiucible kinase) ; Prk (proliferation-related kinase) ; Sak (Snk akin kinase) xvi Table II: Polo- like kinase ... hours after transfection Caspase-3 activity assay was carried out (Fig 8) and intrigued to find that caspase-3 activation in si-PLK1 transfected Huh-7 was absent in th...