... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathwa...
... PDZ -domain- containing (FRMPD2) [8] and Ras guanine exchange factor (RasGEF) veryKIND (v-KIND, or kinase noncatalytic C-lobe domain containing 1) [9] The KIND domain in these proteins is localized to the ... determined the structural and functional properties of the protein protein interaction between v-KIND and MAP2 We defined the binding core regi...
... C An et al Manduca sexta Spatzle ¨ Introduction A prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function ... gene In the clade including Spatzle- 1, the branch lengths are noticeably longer and ¨ the bootstrap values are lower than in the other clades containing...
... Attenuation of LXF-289 cell proliferation by ATP is mediated by the activation of the MEK ⁄ ERK1 ⁄ 2, PI3K and p38 MAPK pathways Activation and translocation of the transcription factors NF -jB1 (p50) and ... Table Inhibition of proliferation of LXF-289 lung tumor cells Effects of signaling pathway inhibitors on ATP-inhibited proliferation (A)...
... Lys282 and Arg315 are involved in catalysis The alignment of the small CMLEs from different members of the Rhizobiales with these sequences demonstrated that in A radiobacter S2 (and the other ... CMLE1s from members of the Rhizobiales, such as ArCMLE1 and AtCMLE1, are significantly shorter than the isofunctional enzymes from other bacteria (Fig 2) Expression...
... STRUCTURE AND FUNCTION OF THE ARABIC VERB Structure and Function of the Arabic Verb is a corpus-based study that unveils the morpho-syntax and the semantics of the Arabic verb Approaches to verbal ... very indicative, in our opinion, of the adequacy and the basis of this orientation, on the one hand, and the destiny of linguistics, o...
... Unveiling iodine’s mechanism of action is of crucial importance Verifying the protective effects of iodine in breast cancer pathways will improve our understanding of breast cancer physiology and ... significant increase in mRNA levels (Figures 2B and C) Discussion As the body of evidence builds, the importance of iodine on the maintenance of healthy breas...
... with mutations was higher in the FLS than in matched synovium This is most probably because the cells bearing mutations in the intact tissue (synoviocytes in the intimal lining) represent only about ... between mutations and the synovial invasion has not been systematically examined In the present study, we first examined paired samples of synoviocytes isolated from t...
... rapidly than broadly expressed ones [5-7] We have studied the relationship between the phyletic age of a protein and its expression profile, and related this to the function of the protein The ... analysis FuncFunctional File usedof of thethe proteins analysis analysis Phyletic Additionalforof of the proteins usedused used thethe The sequences the the analysi...
... transcription factor function The combined results of these studies have expanded our current understanding of the expression and function of the PRL family of enzymes as well as of the role these important ... Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Expression and Function of the PRL Family of Protein Tyro...
... synthesize first 29 strand cDNA as well as whole p53 gene The 5’ end of the forward primer starts from the start codon of p53 gene and in case of reverse primer the 5’ end starts just after the ... Regulation of p53 dependent DNA-repair target gene promoters 60 by p53Pro and p53Arg variants VI 3.2.2.1 Expression of Gadd45 promoter in presence of either...
... the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this siRNA 72 hours after the transfection, the cells ... that it was a candidate tumor suppressor gene The over-expression of DLEC1 in hepatocellular carcinoma (HCC) cell lines such as HepG2 and SK-Hep-...