Implementation of a drug discovery tool for the evaluation of anti fibrotic compounds application in fibrovascular disorders
Implementation of a drug discovery tool for the evaluation of anti fibrotic compounds application in fibrovascular disorders
... salt Graduate Program in Bioengineering 22 Chapter Literature Review DexS has a widespread application in medical industry as an anti- coagulant agent and as ingredients of cream and ointment for ... was trypsinized and replated at a ratio of 1:5 Trypsinization was performed by incubating the cells in a minimal amount (1ml for T-75 flask) of Trypsin-EDTA (1x) for at 37ºC The trypsin was then ... potentially suitable collagen quantification assay as a building block of a discovery tool for anti- fibrotic drugs Graduate Program in Bioengineering vi List of Tables List of Tables Table 3.1 The filter...
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Báo cáo y học: "ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data" docx
... above the significance cutoff, 'array density' of the peak, and the P value for that peak The array density value is defined as the average number of arrayed elements used to calculate the window ... than half of the array resolution, with array resolution defined as the distance between the start of one arrayed element and the start of the next Thereby, the measurement recorded at each arrayed ... ssia ion reg Gau -1 Simulated data mean = Standard deviation = 0.35 -4 -2 The type of microarray used in a ChIP-chip experiment affects how the data can be analyzed Two array designs are typically...
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Báo cáo khoa học: "A Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study" pptx
... for diagnosis or monitoring as part of standard care Given their value in evaluating and managing patients with heart failure, the natriuretic peptide class of biomarkers might be useful as a ... Because hemodynamic monitoring is a frequent theme in the evaluation of patients in the ICU setting, there may be logic behind evaluating ICU patients by testing for B-type (brain) natriuretic peptide ... from the same cohort, with two patients in the previous data set removed because of lack of NT-proBNP data and two patients without BNP data in the prior analysis added, leaving the same number of...
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Applying side effects of anti fibrotic compounds to promote neovascularization for tissue engineering
... The use of anti- fibrotic substances to minimize and reduce the formation of a fibrotic sheath around an implanted tissue engineered construct would therefore be of great benefit in tissue engineering ... Fibrosis in Tissue Engineering – A Result of Foreign Body Reaction and Wound Healing Regenerative medicine and tissue engineering often inevitably require surgery for implantation of tissue engineered ... factors, the use of exogenous angiogenic factors alone may not produce functional vascular networks Instead of trying to optimize a recipe of cells and growth factors for vascularization to occur,...
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Applying side effects of anti fibrotic compounds to promote neovascularization for tissue engineering 1
... Tissue Engineering 1. 2 HIF -1 : An Alternative Approach to Neovascularization 1. 3 Regulation of HIF -1 1.4 HIF -1 Target Genes 1. 5 HIF -1 Promotes Angiogenesis 1. 6 HIF Prolyl 4-Hydroxylases 1. 7 Prolyl ... 4-Hydroxylase Inhibitors (PHi) Promote Angiogenesis by Stabilizing HIF -1 1. 8 In Vitro Angiogenesis Assays 12 1. 9 In Vivo Angiogenesis Models 14 1. 10 Fibrosis in Tissue Engineering – A Result of Foreign ... and Wound Healing 19 1. 11 Collagen Biosynthesis 21 1 .12 Inhibition of Collagen Biosynthesis Using Prolyl Hydroxylase Inhibitors 22 1. 13 Selection of Prolyl 4-Hydroxylase Inhibitors 23 ii MATERIALS...
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Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... influence a substrate has on its own removal It is obtained for all substrates of any elementary reaction The main point of the present section is that any Jacobian matrix element equals the sum of a ... is the basis of the graphical analyses of the characteristic equation and of the method we develop here Inspection of Eqn 12 shows that in all coefficients ap the term consisting of negative half-steps ... oscillations The main result of such an analysis is that oscillations arise if the parameter k3 is the largest and the parameters k6 and k7 are the smallest in the system Oscillations in this system can...
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Báo cáo khoa học: "A TOOL FOR THE AUTOMATIC CREATION, EXTENSION OF LEXICAL KNOWLEDGE" pdf
... the basis of existing ones and on the basis of primitive linguistic and lexicographic procedures, and checking the output of the constructors before it is added to the dictionary The aim of the ... on or off by the user) The result of applying this constructor to the MD is the extension of each entry in it with an additional field (or slot at the knowledge level) for the tran- 73 the architecture ... the lexical representation, the pronunciation, the citation form (lexeme) and some morpho-syntactic codes of the verb form werkte (worked) (Records for citation forms contain pointers to the...
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A visualization tool for the rapid analysis of bacterial transcriptome data pot
... that enables visualization of transcriptome data onto a linear map of an annotated bacterial genome and at the same time highlights additional features, such as putative regulatory sequences and ... terminators The combination of information extraction and visualization facilitates rapid, easy and intuitive analysis of genomics data, and in our research group Genome2D proved to be of great assistance ... of visual inspection of transcriptome data compared with statistical analyses, which we Second, visualized transcriptome data can reveal putative transcriptional readthrough For example, in the...
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báo cáo khoa học: "Use of RE-AIM to develop a multi-media facilitation tool for the patient-centered medical home" potx
... implementation of strategies at a reasonable cost; and lead to maintained self-management in patients and sustained delivery within primary care clinics [19,35,36] RE-AIM can be a valuable planning tool ... Connection to Health Patient Self-Management System is designed to deliver an array of tools to assist patients and providers in the assessment, monitoring, and management of a variety of health behaviors, ... Methods The RE-AIM planning and evaluation model was used to develop a multimedia, multiplehealth behavior tool with psychosocial assessment and feedback features to facilitate and guide patient-centered...
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Báo cáo y học: " Development and evaluation of a tool for the assessment of footwear characteristics" pdf
... as the average of the height medially and laterally from the base of the heel to the centre of the heel-sole interface Forefoot height (measured at point of first and fifth metatarsophalangeal ... collection and analysis, and with DB collected all data All authors were involved in the development of the scale and the interpretation of the results, helped draft the manuscript, and read and approved ... shoes, and sandals The range for each quantitative measure from the included footwear can be found in Table Intra-rater reliability Intra-rater ICCs and 95% LOAs for quantitative measures are shown...
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Báo cáo y học: "Investigating the complementary value of discrete choice experiments for the evaluation of barriers and facilitators in implementation research: a questionnaire survey" pptx
... facilitators to the implementation of the guideline for breast cancer surgery in day care The objective of our study was to investigate the complementary value of DCE for the evaluation of barriers ... research presented in the present paper was part of a larger research project entitled 'Investigating the added value of conjoint analysis for the evaluation of barriers and facilitators in implementation ... contributions to the conception and design of the study, the acquisition, analysis and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intellectual...
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báo cáo khoa học: " NorthStar, a support tool for the design and evaluation of quality improvement interventions in healthcare" ppt
... what and how of measuring baseline performance defined as the measurement of actual clinical practice and its comparison to desired clinical practice (Measuring Baseline Performance) NorthStar ... evidence-based clinical practice NorthStar is a major product of the ReBEQI project It is a software program that packages information on the design and evaluation of evidence-based QI interventions into ... evaluation study design Determinants of practice are the factors that affect practice patterns and explain the variation in the effectiveness of different QI interventions in changing practice patterns;...
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báo cáo khoa học: " Whole-Organ analysis of calcium behaviour in the developing pistil of olive (Olea europaea L.) as a tool for the determination of key events in sexual plant " ppsx
... showed the accumulation of Ca/Sb precipitates in the vacuoles of the stigma cells as well as in the intracellular spaces between them The stigmatic surface is the main place for signal exchange ... precipitates The spectrum of the material reveals peaks for Ca and Sb The strong decrease of the Ca2+ pool in the pistil at the last stages of pistil development coincides with the degradation of the ... 3-fold in comparison with that found in stage A more detailed analysis of the changes in the olive pistil Ca2+ pool was performed using the separated parts of the pistil: stigma with style and ovary...
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báo cáo khoa học: " Investigating the complementary value of discrete choice experiments for the evaluation of barriers and facilitators in implementation research: a questionnaire survey" pot
... presented in the present paper was part of a larger research project entitled 'Investigating the added value of conjoint analysis for the evaluation of barriers and facilitators in implementation studies: ... facilitators to the implementation of the guideline for breast cancer surgery in day care The objective of our study was to investigate the complementary value of DCE for the evaluation of barriers ... preferences of those concerned with the actual implementation The objective of our study was to investigate the complementary value of DCE for the evaluation of barriers and facilitators in implementation...
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