Effects of central nervous system free fatty acids, prostaglandins and lysophospholipids on allodynia in a mouse model of orofacial pain

... infection and neoplasms Neuralgic pain is generally expressed in the facial area as idiopathic trigeminal neuralgia The ill-defined category of atypical oral and facial pain includes a variety of pain ... hyperalgesia, and in the area of normal tissue surrounding the injury site, as secondary hyperalgesia (c) Phase (Neuropathic Pain) These are abnormal pain states and are defined as pain initiated or caused ... have also indicated central involvement of excitatory amino acids in trigeminal nociception (Parada et al., 1997) Methods of Assessing Pain in Animals Pain research and therapy during the past...

Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain

... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the area of injury is also known as ... sensibility including touch and thermal sensation without pain, as well as to pain Hyperesthesia includes both allodynia and hyperalgesia Hyperpathia is defined as a painful syndrome characterized by an...

Báo cáo y học: "Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonis" ppsx

... Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism Kyle D Allen1,2, Mohammed F Shamji1,3, Brian A Mata2, ... during the early phase of lumbar radiculopathy may distinguish a focal unilateral pathology of lumbar radiculopathy from the generalized pain syndrome of lumbar spinal stenosis and IVD degeneration ... is the first study to investigate gait dynamics associating with lumbar radiculopathy in a rat model Amongst measures of gait dynamics, vertical impulse appears to be strongly affected by lumbar...

Effects of serial passaging on west nile virus (sarafend) in a mouse model

... VIRUS (SARAFEND) 67 3.2.1 Infection of Adult Mice with West Nile Virus (Sarafend) 67 3.2.2 Infection of Suckling Mice with West Nile Virus (Sarafend) 68 3.3 PASSAGING OF WEST NILE ... POTENCY OF PASSAGED WEST NILE VIRUS (SARAFEND). 88 vi | P a g e Table of Contents 4.3 INFECTION OF ADULT BALB/C MICE WITH PASSAGED WEST NILE VIRUS (SARAFEND) 91 4.3.1 Levels of Viremia in Various ... fatal encephalitis About 20 percent of infected patients display a range of symptoms including fever, headache, malaise, back pain, myalgias, eye pain, pharyngitis, nausea, vomiting, diarrhoea,...

Báo cáo khoa học: Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I pdf

... [7], although kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase ... (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein name ApoA4 ActB ... version 5.0 software (GeneBio, Geneva, Switzerland), including spot detection, quantiﬁcation, normalization, data analysis and statistics Comparative analysis of protein spots was performed by matching...

Báo cáo sinh học: "Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma" pptx

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; Cr: Creatinine Acknowledgements ... suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma Journal of Translational Medicine 2011 9:39 Submit your next manuscript...

Báo cáo sinh học: "Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer" pdf

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscript to BioMed Central and take full advantage ... vaccination with mGC8 cells and GM-CSF T cells generated from TVDLN at day nine after vaccination were polyclonally activated and expanded as described in the Methods section and tested for tumorspecific...

báo cáo hóa học:" Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma" doc

Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt

... to a number of factors, including the longevity of the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained ... increase the affinity of the DNase I for DNA, resulting in two improved characteristics – increased specific activity compared to the wild-type enzyme and elimination of the inhibition by salt at ... Our findings indicate that the presence of a mutant DNase (ash .DNase I) , resistant to inhibition by serum G-actin, resistant to inhibition by physiological saline and hyperactive compared to the...

Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance docx

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility are clinical features ... selection and data analysis All array data were deposited in the NCI-CIT microarray database [65] where Cy3 and Cy5 signals were median normalized and expression ratios (Cy5/Cy3) were calculated The...

báo cáo khoa học: " Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model" pot

... 3D models as a reasonable amendment in craniofacial reconstruction that offers multiple advantages They facilitate surgical planning by demonstrating the anatomical characteristics of the tissue ... providing them with a better understanding of the process and its possible outcomes Virtual planning and the use of rapid prototyping have been used mainly in craniomaxillofacial surgery Because of ... journal Author details Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, The Netherlands 2Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen...

báo cáo khoa học: " Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model" pptx

... this article as: Kleinheinz et al., Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model Head & Face Medicine 2010, 6:17 Page of ... processed according to a standard protocol In short, they were fixed, dehydrated in increasing gradients of ethanol and embedded in paraffin Thin sections were sliced, stained according to an azan standard ... conceived of the study, and participated in its design and coordination and helped to draft the manuscript CF and UJ were involved in revising the article All authors read and approved the final manuscript...

Báo cáo y học: " Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma" doc

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the effects of VD on airway inflammation, a separate ... down-regulated NPRA expression We have reported that NPRA plays a role in airway inflammation Knockout of NPRA in mice resulted in less lung inflammation [11] Inhibition of NPRA by small inferfering...

Báo cáo y học: " GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma" ppt

... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of allergen challenge, resulting in a ... Respiratory Research 2009, 10:93 Background Allergic asthma is an inflammatory disease characterized by reversible airway obstruction, and is associated with airways hyperresponsiveness (AHR)...

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