Characterisation of a bHLH PAS transcription factor, NPAS1
Characterisation of a bHLH PAS transcription factor, NPAS1
... transfected with GAL4 NPAS1 1-70 Lane c: GAL4 NPAS1 71-165 Lane d: GAL4 NPAS1 206-290 Lane e: GAL4 NPAS1 302-354 Lane f: GAL4 NPAS1 348-403 Lane g: GAL4 NPAS1 404-507 Lane h: GAL4 NPAS1 501-594 The ... physiological events Expression of NPAS1 Murine NPAS1 or neuronal PAS domain protein is 595 amino acids long and it contains a bHLH domain with two PAS domains (PAS A & PAS B) and a PAS associated ... domain and part of the PAS A domain) and NPAS1 166-354 most of the PAS B domain) and NPAS1 (containing a polyserine region and 348-507 into two parts NPAS1 348-403 (containing part of the PAS...
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Báo cáo khoa học: Novel repressor of the human FMR1 gene ) identification ¨ of p56 human (GCC)n-binding protein as a Kruppel-like transcription factor ZF5 ppt
... siRNA selection [43] The first siRNAZF5 5¢-GGUUGAGGAUGUGAAAUUCUU-3¢ and 5¢-GAAUUUCACAUCCUCAACCUU-3 ) matched bases 192–210; the second siRNAZF5 (5¢-GAGGAAGCAUGA GAAACUCUU-3¢ and 5¢-GAGUUUCUCAUGCUUCCU ... human (GCC)n-binding protein Fig Identification of p56 polypeptide as Kruppel-like transcription factor ZF5 by MALDI-TOF assay (A) Fragment of MALDI-TOF spectrum of ¨ p56- derived peptides (B) Mascot ... FMR1 gene These data clearly support the assertion that endogenous ZF5 acts as a transcriptional repressor of the human FMR1 gene Given that FMR1 inactivation in FMR patients has been attributed...
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báo cáo khoa học: " Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses" ppt
... et al.: Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses BMC Plant ... 5’-TAC CAT GGA CAT GTT TAC TAT GAA TCA ATT-3’ (Nco I site underlined) and 5’-ATA CTA GTT TAA AAT GAG TAA CTC CAC A- 3’ (Spe I site underlined) An NcoI-SpeI fragment containing MtCBF4 cDNA was inserted ... reveal that MtCBF4 was induced by ABA, drought, salt, and cold stimulation, indicating that it might play an important role in response to abiotic stresses and ABA treatment Over-expression of MtCBF4...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... to assemble with members of the ethylene response factor ⁄ Apetala2 (ERF ⁄ AP2) transcription factor family We also provide a detailed description of the Arabidopsis thaliana BPM family expression ... proteins assemble with members of the ERF ⁄ AP2 transcription factor family Because it has been shown previously that Arabidopsis BPM proteins use their BTB ⁄ POZ domain to interact with the cullins ... BPM proteins interact with members of the ERF ⁄ AP2 family (A) Y2H assays demonstrate the assembly of BPM1(1–189) and BPM3 with RAP2.4 and RAP2.13, respectively (B) Schematic drawing of the BPM1...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... (0.04) (0 .19 ) (0.09) 19 83 2493 14 86 18 85 10 30 16 30 13 45 10 38 19 60 805 514 (406) (13 74) (780) ( 710 ) ( 613 ) (809) (740) (542) (10 47) (752) (277) 19 64 15 61 1008 15 96 905 12 97 11 42 468 14 03 276 206 ... S1 Bar graph of R1, R2 and {1H} 15 N NOE values along the sequence of the TTF1 HD at 11 .7 T and 286 K 448 Fig S2 Plot of J(0.87xN)–J(0) correlation from 15 N relaxation measurements of the TTF -1 ... dynamics of the HD recognition helix upon DNA binding [11 ] 436 In the following, we present a 15 N-NMR relaxation study of the rat TTF -1 HD to address the backbone dynamics in solution 15 N-NMR...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
... Roles of the heat shock transcription factors in regulation of the heat shock response and beyond FASEB J 15, 1118–1131 Voellmy R (2004) On mechanisms that control heat shock transcription factor ... HSE-type specific recognition by human HSFs resulted in robust activation by hHSF4–VP16, without changing the magnitude of the heat shock response (cp3) The mutational analysis of the CRYGA and CRYGC ... (2007) Different mechanisms are involved in the transcriptional activation by yeast heat shock transcription factor through two different types of heat shock elements J Biol Chem 282, 10333–10340 10...
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Báo cáo khoa học: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA docx
... monomer to another, which is often the hallmark of binding of dimeric transcription factors to palindromic DNA sequences [1–5] Although it adds complexity to the system, allostery confers upon transcription ... Results and Discussion Basic residues cooperate in driving the binding of the Jun-Fos heterodimer to DNA To understand how basic residues drive the binding of the Jun-Fos heterodimer to DNA with ... pair of single-alanine mutants of the Jun-Fos heterodimer analyzed alone and in combination with each other with respect to binding to DNA relative to the wild-type proteins The complete thermodynamic...
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Báo cáo khoa học: "Characterisation of a GII-4 norovirus variant-specific surface-exposed site involved in antibody binding" docx
... A and site B form a conformational, variant-specific, surface-exposed site on the GII-4 norovirus capsid that is involved in antibody binding, and that as predicted, significant amino acid changes ... reagents, participated in the coordination of the study and editing of the manuscript MIG participated in the design and coordination of the study, analysis of the data and drafting and editing of the ... demonstrate that site A and site B were important for antibody binding, and more detailed mutagenesis studies where individual amino acid residues in the GII-4v2 VLP were mutated would aid in revealing...
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Báo cáo khoa học: "Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N" pps
... 5'ATTTAAGGATCCGAGAGCCATGGA 3' 5'ATGCTGCTCGAGTTATATACAAATGTTGC 3' 5'CATAGAATTCGCAAAAGCAGGAGT 3' 5'TATCGCTCGAGAGTAGAAACAAGGAG 3' 5'AGCCTGGAATTCATGAAAAAATTA 3' 5'CTCACTCGAGACATTTTCAGGGA 3' aIn all of the above mentioned ... AGCCTGGAATTCATGAAAAAATTA 3' 5' ATCGAACTCGAGATTTTCAGGGAT 3' 5' AGGGCTGGCGGTTGGGGGTTATTCGC 3' 5' GAGTCACTTTAAAATTTGTATACAC 3' 5' GATGTTAACGATACCAGCC 3' 5' GCGTGAATGTAAGCGTGAC 3' 5'ATTTAAGGATCCGAGAGCCATGGA 3' ... pC-HA-F pC-HA-R pC-NA-F pC-NA-R pC-P1-FP pC-P1-RP 5' CATAGAATTCGCAAAAGCAGGAGT 3' 5' TATCGCTCGAGAGTAGAAACAAGGAG 3' 5' ATTTAAGGTACCGACAGCCATGGA 3' 5' ATGCTGCTCGAGTATACAAATGTTGC 3' 5' AGCCTGGAATTCATGAAAAAATTA...
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Development and characterisation of a high performance distributed feedback fibre laser hydrophone
... fibre laser hydrophone with high and flat sensitivity up to kHz for thin-line array application The inherent advantages of fibre laser hydrophones are their intrinsic safety to water leakage, ease of ... the laser mode that matches the reflection band of the Bragg grating will result in a narrow line width laser generation Narrow bandwidth laser can be generated by careful selection of Bragg grating ... chapter presents a miniature pressure compensated metal diaphragm based fibre laser hydrophone capable of measuring acoustic signals as small as sea state zero noise levels and a flat frequency response...
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DESIGN AND CHARACTERISATION OF a CONTINUOUS ROTARY DAMPER WITH IDEAL VISCOUS DAMPING PROPERTIES
... to design a viscous damper with linear damping properties, it would be necessary to take a look at damping as a whole, as well as commercial viscous dampers that are already available 3.1 Damping ... using a damping component with a variable damping coefficient, the SDA would be a versatile force control actuator and applicable at both low and high force applications 19 Chapter - Damper Design ... to the damper design, the damper cannot rotate past 360⁰; most such dampers are able to rotate about 120⁰ 23 Continuous rotary dampers (CRD) are dampers that are able to rotate freely past 360⁰...
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DESIGN AND CHARACTERISATION OF a CONTINUOUS ROTARY DAMPER WITH IDEAL VISCOUS DAMPING PROPERTIES
... to design a viscous damper with linear damping properties, it would be necessary to take a look at damping as a whole, as well as commercial viscous dampers that are already available 3.1 Damping ... using a damping component with a variable damping coefficient, the SDA would be a versatile force control actuator and applicable at both low and high force applications 19 Chapter - Damper Design ... to the damper design, the damper cannot rotate past 360⁰; most such dampers are able to rotate about 120⁰ 23 Continuous rotary dampers (CRD) are dampers that are able to rotate freely past 360⁰...
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Identification and characterisation of a mads box gene from rafflesia cantleyi solms laubach (rafflesiaceae)
... 361 TGCATTTCAATAACAAAGAGAAGCCAAGCCAGCCATCTCTTGAACTGCAGCTAGAAATTA 420 72 L H F N N K E K P S Q P S L E L Q L E I 91 421 GCAATCGGGTGCGACTGAGCAAAGAAGTTGCAGACAAGACTCGCCAACTAAGGCAAATGA 480 ... 541 AGGTGGGCCTCCAGCGCGTTACTGATGCCAAGGGCAAGCGCATCACAAATGAGATATCTG 600 151 132 E V G L Q R V T D A K G K R I T N E I S 601 AACTCGAAAGGAAGGGAGCGCAGCTGATGGAAGAAAATAAGCAACTAAAGCAAAAAATGG 660 ... 1 GGGTTAGGTTTCCATATGCCCCACGGGCCACATATTCTTGAACCTGTCTAGCCTTCCCCA 60 61 ATTTATTGCCCGAAGCTGTACGTTCATATTTCGAAACTAAAGATTCGGTCGTGCCGTATT 120 121 TGTTCTGTTTCGGAGCAGATAATATAATGGCTCGAGAAAAGATCAAGATCAAAAAGATCG 180 1 M A R E K I K I K K...
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Characterization of NPAS1, a transcription factor that regulates tyrosine hydroxylase expression during dopaminergic neuron development
... CHARACTERIZATION OF NPAS1, A TRANSCRIPTION FACTOR THAT REGULATES TYROSINE HYDROXYLASE EXPRESSION DURING DOPAMINERGIC NEURON DEVELOPMENT TEH HUI LENG CHRISTINA (B.Sc(Hons), NUS) A THESIS ... cleavage generating an amino-terminal cleavage product of approximately 20 kDa that has been implicated in mediating signaling activities in Drosophila (Lee et al, 1994; Porter et al, 1995) and ... et al., 2004) 18 Introduction 1.7.1) Mechanism of bHLH/PAS protein signaling The PAS domain is made up of two adjacent degenerate repeats of ~130 amino acids, PAS A and PAS B The domain is an ancient...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... ⁄ Akt signaling was not necessary for EGFinduced protection of TMK -1 cells against apoptosis Role of AP1 in EGF-mediated cell protection A B C MAP kinase signaling provides an alternative pathway ... induced by DNA-damaging agents Oncogene 17 , 13 1 14 1 15 Geier A, Beery R, Haimsohn M, Hemi R, Malik Z & Karasik A (19 94) Epidermal growth factor, phorbol esters, and aurintricarboxylic acid are survival ... the MAP kinase cascade [49] Our study showed that EGF caused a substantial increase in AP1 DNA binding In addition, this increase was prevented by MAP kinase kinase inhibitor PD98059 (Fig 5A) The...
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