... in the absence of inflammatory mediators known to dominate the effector phase of CIA Both arthritogenic and non -arthritogenic mouse mAbs to CII were shown by immunofluorescence to penetrate cartilage ... fragments of CII, respectively [8,10], and CIIF4 [22] is a nonarthritogenic mAb that binds to a conformational epitope on the CB9 fragment [8] CIIC1 and M2139 either individually, or in combination, induce ... Hellstrom S, Holmdahl R, Kleinau S: Induction of arthritis by single monoclonal IgG anti -collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB Eur J Immunol 2003,...