Integrating biological insights with topological characteristics for improved complex prediction from protein interaction networks

... catalogued, distinct groups of proteins forming complexes can be isolated from them: proteins within a complex form many interactions with each other than with proteins not in the complex Quite naturally, ... protein interactions from an organism are typically assembled in the form of a network with the proteins as nodes and the interactions among them as edges, commonly called protein- protein interaction ... detected complexes 112 5.5 Lessons from employing functional interactions 114 Protein essentiality and periodicity in complex formations 6.1 Role of protein essentiality in complex...

Báo cáo hóa học: " Research Article Unequal Weighting for Improved Positioning in GPS-Less Sensor Networks" pot

... neighbors In the beginning, local coordinates are computed only for the cluster of nodes within the same radio range Later, those local coordinates are consolidated into an overall base for the ... not include the shrinking areas but only the dark-shaded growing areas All the other weights π k=3 actually include the shrinking areas in their product Note that all weights π k=3 except for ... radius In contrast, a linear structure increases proportional only to its length Though the slim patch has an area as well, it’s growth does not result in a signiﬁcant gain in the beginning Put into...

Association of intervention outcomes with practice capacity for change: Subgroup analysis from a group randomized trial ppt

... repeated measures made at each practice Separate models were developed to assess the association between the combined practice capacity for change score and change in the practice rate of PSD from ... score, a supplemental analysis demonstrated a strong association with instrumental change capacity (3.2%, p = 0.002); a weaker association with motivation to change approached significance (2.1%, ... preventive care at a subset of practices estimated to have the highest and lowest capacity for change Each box and bracket represent the mean and standard deviation, respectively, for PSD rates at assessments...

báo cáo khoa học: " Association of intervention outcomes with practice capacity for change: Subgroup analysis from a group randomized trial" potx

Báo cáo y học: "Cross-species cluster co-conservation: a new method for generating protein interaction networks" docx

... likely noise Addressing this limitation is an important area for continued effort Data availability Data are available upon request Abbreviations BFS, breadth-first search; CC, co-conservation; ... million years ago (MYA) from O157, an estimated 100 MYA from Salmonella, 200 MYA from Pseudomonas, and 1,200 MYA from Bacillus Thus, we examined a combination of pathogenic and non-pathogenic organisms ... its ability to analyze only a single species at a time In contrast, CS-CCC examines each cluster across multiple species and reveals interactions that both homology-based methods and CCC fail...

Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx

... hypothetical protein- protein interaction network Each sphere represents a protein and the connecting lines represent protein- protein interactions Within an interaction network, smaller local interaction ... and independently fusing these domains with candidate interacting proteins [21,22] Constructs encoding these fusion proteins are transformed into yeast cells; if the two candidate proteins interact ... can now be inferred from clustering within the HD protein- protein interaction network, a more directed research strategy can be used when investigating these proteins The recent study by Goehler...

Computational methods for identifying conserved protein complexes between species from protein interaction data

... thesis A survey on computational methods for identifying conserved protein complexes between species: in this survey, computational methods for identifying conserved protein complexes are grouped ... present a definition for the problem of identifying conserved protein complexes between species from protein interaction data We then review the existing computational methods for this problem and ... 2.2 – The computational pipeline for identifying conserved protein complexes 2.2.4 Result evaluation for conserved protein complexes Detected conserved protein complexes need a benchmark dataset...

Computational methods for identifying conserved protein complexes between species from protein interaction data

Báo cáo khoa học: "A PARAMETERIZED APPROACH TO INTEGRATING ASPECT WITH LEXICAL-SEMANTICS FOR MACHINE TRANSLATION" doc

... developed for the automatic acquisition of novel lexical entries for machine translation 16 We are in the process of building an English dictionary, and intend to use the same approach for building ... [-a] predicate into a [+a] predicate, i.e., a non-atomic event becomes atomic if it is associated with a singular NP object The parameterized mappings that we have constructed for Spanish are ... Once the aspectual features have guided the lexical selection of the verbs, we are able to use these selections to guide the aspectual realizations that will be used in the surface form For example,...

Báo cáo hóa học: " Research Article Integrating the Projective Transform with Particle Filtering for Visual Tracking" potx

... (iii) an evaluation of the resampling accuracy for the projective particle filter; (iv) a comparison of the performance of the projective particle filter and the standard particle filter using three ... (1) the improvement in sample distribution with the implementation of the projective transform, (2) the improvement in the position error of the vehicle by the projective particle filter, (3) the ... number of particle filter iteration The average resampling frequency for the projective particle filter is 14.9%, and 19.4% for the standard particle filter In the first experiment, the performance...

Báo cáo y học: "Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers" docx

... by trypsin treatment (0.05% trypsin, 0.02% EDTA; Biochrom) at 75% confluence Flow cytometry analysis of cells Either isolated cells from OC were directly used for flow cytometric analysis or cells ... functionality of cell surface molecules on human mesenchymal stem cells J Biomed Sci 2003, 10:228-241 Reyes M, Verfaillie CM: Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal ... analysis of fresh isolated chondrocytes from osteoarthritic cartilage (a) Forward/side scatter (b) Markers were cartilage set in the channel display with a maximum of 2% positive cells by staining...

báo cáo khoa học: "The importance of organizational characteristics for improving outcomes in patients with chronic disease: a systematic review of congestive heart failure" pdf

... article as: Leykum et al.: The importance of organizational characteristics for improving outcomes in patients with chronic disease: a systematic review of congestive heart failure Implementation ... effectiveness of combinations of characteristics Because one way that individuals can navigate uncertainty is through relationships, interconnections may be particularly important with increasing uncertainty ... that an important reason for this variation in outcomes is that interventions not adequately take into account the characteristics of clinical systems in which patients receive care Clinical...

Composite nonlinear feedback control for systems with actuator saturation towards improved tracking performance

... CNF Control for Continuous-Time Systems with Input Saturation In this chapter, I will present a design procedure of composite nonlinear feedback control for general multivariable systems with actuator ... procedure of composite nonlinear feedback (CNF) control for general multivariable systems with actuator saturation I will consider both the state feedback case and the measurement feedback case without ... satisfactory performance Finally, some concluding remarks will be drawn in Section 2.4 Chapter CNF Control for Continuous-Time Systems with Input Saturation 2.2 15 Composite Nonlinear Feedback Control for...

Báo cáo y học: "MALDI-TOF MS Combined With Magnetic Beads for Detecting Serum Protein Biomarkers and Establishment of Boosting Decision Tree Model for Diagnosis of Colorectal Cancer"

... conclusion, MALDI-TOF MS combined with magnetic beads is one useful tool for integrating separation and analysis of complex mixtures of proteins With the panel of four selected biomarkers, we achieved ... a by serum protein profiling of patients with chronic liver diseases Hepatology 2005; 41:40-47 28 Cho WC, Yip TT, Ngan RK, Yip TT, Podust VN ProteinChip array profiling for identification of ... specific for CRC (Figure 2, 3) Figure Representative protein spectrum of separate analyses from CRC patient and control by MALDI-TOF MS combined with WCX magnetic beads, showing the protein m/z...

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