... severaland step series of reactions involvingring opening and amide formation with pyrrolidine,oxidationtothealdehyde,epimerization,reduction ,and ether formation ledto amide [34] Ozonolysis and ... theunexpectedloss of tosylate and aziridine formation Olefin formation from [56] via the N-oxide and chain extensiongaveacid [57J Iodolactonization and tri-n-butyltin hydride reduction in thestandard fashion ... EnantiomericailyPure Drugs 209 H0 108 109 R = CH(CH,)OCH,CH:, R2 SI(CeH&C(CH& HO' H 79 FIGURE Continued 19 the carbonate, protectionof the primaryand secondary hydroxyl groups as a tosylate and ethoxyethyl...