The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy

... THE STUDY OF INTERACTIONS OF TRANSMEMBRANE RECEPTORS AND INTRACELLULAR SIGNALING PROTEINS IN LIVE CELLS BY FLUORESCENCE CORRELATION AND CROSS -CORRELATION SPECTROSCOPY LIU PING (M.Sc), CAS A THESIS ... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain ... ligands bind to the extracellular domains of two receptor subunits and form a 2:2 complex (42), resulting in activation of the intracellular kinases of the receptors Upon ligand binding, the...

Development of a novel toll like receptor based two hybrid assay for detecting protein protein interactions and its application in the study of CD14 dimerization and FcyRIIA activation

... complex The IRAK4/IRAK1/TRAF6 complex interacts at the membrane with another preformed complex consisting of TGF-βactivated kinase (TAK1) and its two adaptor proteins, TAK1-binding protein (TAB) and ... of the nature of the interactions, the temporal and spatial combinations of these interactions can generate considerable functional diversity by triggering distinct signaling cascades and leading ... Chapter 6.1 Discussion Development of a TLR -based two- hybrid assay for the detection of proteinprotein interactions 6.2 158 Investigation of CD14 dimerization and its role in CD14 signal transduction...

The Study of Service Quality and How It Influences Student Satisfaction in Phương Đông College.

... The Study of Service Quality and How It Influences Student Satisfaction in Phương Đông College Free Powerpoint Templates Introduction Theoretical Framework and Hypothesis Development ... Perceived quality and objective quality Quality and satisfaction Service quality and its Dimensions Free Powerpoint Templates Page 10 Free Powerpoint Templates Page 11 2.1 Definition of SERVQUAL ... understand the actual quality of our services like library resources, writing center, and so on… Free Powerpoint Templates Page • This study is intent to understand: Conception of service quality...

Báo cáo y học: "Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis" pot

... some of the expression studies AP performed many of the expression studies and the ChIP-chip analysis VL performed the ChIP-chip analysis CD participated in the design and printing of the array and ... intensity across the whole array http://www.retrovirology.com/content/1/1/10 Authors' contributions EG analyzed all the microarray data and printed the arrays NM printed the arrays and participated ... ratio of this mean on the average of the intensity across the array set was then obtained A ratio greater than indicates that there was hybridization to a specific gene 2-fold above the background...

On applying network coding to wireless ad hoc networks a study of robustness, efficiency and cross layer synergy

... between network layer and application layer The availability of cross- layer information can greatly help both in network layer and in application layer By taking the oﬀered load information from ... physical radio Without such kind of information, transport and application layers cannot adapt (or react) to the additional physical -layer time-varying constraints such as highly variant jitter ... scheme can be overcome Design a cross- layer solution that jointly considers network conditions in the network layer and in the application layer With the cross- layer approach, the application layer...

Quantification of epidermal growth factor receptor dynamics and interactions in living cells by fluorescent correlation and cross correlation spectroscopy

... for studying rafts is interrupting rafts by changing the amount of cholesterol in cells, which includes increasing its amount by adding in extra cholesterol and extracting it by drug treatments ... thereby enabling the exposure of the ligand-binding pocket of domain L1 and L2 The dimerization arm in domain CR1 is known to facilitate the formation of dimers, which leads to the kinase domain of ... functions of EGFR such as binding with ligands and subsequent activation Interestingly, again, opposing effects were observed in different settings of experiments In artificial 20 membranes, the binding...

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Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf

... steroid synthesis, the release of AA into the mitochondria is the ﬁrst stimulator of cholesterol transport The sustained phase of the acute response will then need the induction of StAR We cannot ... mitochondria The absence of hormone ⁄ cAMP- induced steroid synthesis when protein synthesis is inhibited can be explained now by the inhibition in the induction of 5018 ACS4 [28] during the early ... supports the notion that Acot2 is the thioesterase involved in the release of AA inside the mitochondria Our model explaining how AA is released into the mitochondria also supports the concept that the...

Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"

... analysed the results and drafted the article MS was involved in critically revising the draft JG made substantial contributions to the data analysis GB was substantially involved in the analysis, ... Proportion of medicationorder entry (CPOE) using the Clinical Informacomputerised physician order entry (CPOE) using the Clinical Information System with 95% confidence intervals Hand-written prescribing ... bias in the results and is a limitation of the study Medical errors are among the leading causes of death in the United States In its highly publicised report, the Institute of Medicine estimates...

Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx

... thermodynamic aspects of complex multisite phosphorylation on the one hand, and the speciﬁc and versatile regulation of protein activation required in signaling pathways on the other Results Mathematical ... of the response curve is strongly affected by the two groups of parameters that determine the protein protein interactions: the concentrations of the enzymes relative to the target protein, and ... states and pathways of phosphorylation and dephosphorylation It will be an aim of this study to elucidate the consequences of processing order for the regulatory properties of the target protein...

Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

... in Role of helix and C-termini in bradykinin receptors receptor signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine ... TSIfiAAA N3 38* B1wt B1RB2 B1NB2 B1CB2 B1KB2 B1KB2 ⁄ SfiV B1KB2 ⁄ QGVfiKQ B1KB2 ⁄ VCfiCV B1YB2 B1V323S 10400 5020 52 98 383 2 625 127 511 1701 182 3 17 58 2142 1 786 2957 84 6 3.91 ± 1.06 3.76 ± 1.61 2 .82 ± 0.92 ... Faussner et al Role of helix and C-termini in bradykinin receptors Fig Schematic representation of the C-terminal B1wt and B2wt sequences and chimera thereof The C-terminal sequences beginning at transmembrane...

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