... then assess the consequence of Erk1, Erk2, and Erk1/ 2 disruption in SCF-stimulated mast cells in tissue culture while examining the efficacy of systemic PD0325901 administration in treating mast ... complicating direct pharmacological inhibition of the tumorous mass Therefore, therapeutic strategies targeting components of the tumor microenvironment, including vascular cells and infiltrating mast ... myelopoiesis, and mature effector cell (e.g mast cell) function Global Observations on the Functions of Erk1 and Erk2 Globally, Erk1 and Erk2, 44 and 42 kDa proline-directed protein kinases which...