... c.5106-6 8A> G c.5106-9 2A> G c. 527 2+72G>C c. 527 2+73G >A Polymorphism c .23 3G >A c.4 32- 44G >A (Novel) c. 420 +26 CA>AC(Novel) Blood Blood + Paraffin + FTA cards Frameshift mutation c .28 45insA Missense mutation ... c.4 32- 44G >A, c. 420 +26 CA>AC, c.561-34T>C, c.5106- 138 6 8A> G, c.5106-9 2A> G, c. 527 2+72G>C, c. 527 2+73G >A and c.5451+85delC) Five of these germline variants, c.778C >A, c.4 32- 44G >A, c. 420 +26 CA>AC, c. 527 2+72G>C ... recurrent c .28 45insA mutation in Singapore Malay women Blood from FTA 26 Early-onset (breast/ovarian cancer) 30 Late-onset (breast/ovarian cancer) 56 All (breast/ovarian cancer) Paraffin-embedded...