Statistical learning approaches for predicting pharmacological properties of pharmaceutical agents

... Drug discovery and pharmacological properties of pharmaceutical agents 1.2 Statistical learning methods in characterization of pharmacological properties of pharmaceutical agents ... computational approaches have been explored for predicting various pharmacological properties of pharmaceutical agents In particular, statistical learning methods (SLMs) have shown promise for these ... been evaluated for their usefulness for the prediction of pharmacological properties In this chapter, an overview for drug discovery and pharmacological properties of pharmaceutical agents (section...

Báo cáo khoa học: "A Re-examination of Machine Learning Approaches for Sentence-Level MT Evaluation" ppt

... on one group of MT systems evaluate the translation qualities of new systems? In this paper, we argue for the viability of a regression-based framework for sentence-level MTevaluation Through ... and Chris Brockett 2001 A machine learning approach to the automatic evaluation of machine translation In Proceedings of the 39th Annual Meeting of the Association for Computational Linguistics, ... Koehn 2006 Re-evaluating the role of BLEU in machine translation research In The Proceedings of the Thirteenth Conference of the European Chapter of the Association for Computational Linguistics...

Báo cáo khoa học: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts doc

... investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization and percentage of galloylation, with their antiproliferative potential and their ... potent antioxidant and chemopreventive agent [21,22] These and other results suggest that the galloylation of catechins and the presence of gallocatechin moieties in natural extracts could be ... development of effective and safe agents for the prevention and treatment of cancer remains inefﬁcient and costly, and falls short of the requirements for primary prevention among the high-risk...

Báo cáo khoa học: "Equipment review: The success of early goal-directed therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitation" potx

... that the use of an oximetric central line was not the sole reason for success in the Rivers trial, then are there other resuscitative markers that may serve as adequate endpoints for an early goal-directed ... not in the highest risk category The limitations of these studies notwithstanding, the weight of current evidence suggests that routine use of the PAC is not useful for the vast majority of patients ... Fink What are the primary indications for its use? The primary indication for the use of Presep is as a part of EGDT in the detection and treatment of patients with early sepsis These patients...

Báo cáo y học: "A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study" potx

... died waiting for LT In following analysis we considered the fatal patients and those who were transplanted as one category because the pathological examination showed that the livers of all transplant ... measured using the 7500 Clinical Analyzer (Hitachi High-Technologies Corporation, Tokyo, Japan) LDH was assayed using an enzymatic rate method with lactate as the substrate (lactate- pyruvate direction) ... period According to the normal range of our assay system, the median of the serum LDH was calculated as 174 U/L in this study Statistical analysis Differences in clinical backgrounds and laboratory...

Statistical learning techniques for query

... 294 3.3 Statistical Learning cost We now discuss Comet’s statistical learning component 3.3.1 cost h1, j (vj ) The General Learning Problem Given a set of d features, the goal of the statistical ... ), with wj,i = h1,j (vj,i ) being the value of the transformed jth feature for query qi In statistical- learning terminology, the transformation of vj to wj “linearizes” the jth feature with ... greedy forward stepwise-regression algorithm The resulting model is of the “generalized additive” form Transform Regression For reasons discussed previously, we use the recentlyproposed transform...

ROMP based polymer nanoparticles for the targeted delivery of antitumor agents

... Institute for BioNanotechnology in Medicine Advantages of Polymer Therapeutics “Using advanced polymer chemistry and precision engineering at the molecular level, together with an appreciation of the ... favors polymer formation due to the alleviation of ring strain • Highly functional group tolerant, works at mild temperature • Amenable to the synthesis of monodisperse block copolymers Institute for ... Components of drug delivery system should easily be removed from the organism Institute for BioNanotechnology in Medicine Polymeric Nanoparticles as Model Drug Delivery Vehicles Institute for BioNanotechnology...

Improving the properties of pharmaceutical powders using supercritical anti solvent processing

... decreases the solvent power and the temperature of the fluid and causing the solute to precipitate as microparticles [143] The decrease in the solvent power of the SCF due to the depressurization is of ... IMPROVING THE PROPERTIES OF PHARMACEUTICAL POWDERS USING SUPERCRITICAL ANTI- SOLVENT PROCESSING LIM TAU YEE, RON (B Eng (Hons.), UNIVERSITY OF BATH, U.K.) (M Eng., NUS) A THESIS SUBMITTED ... thus, the absorption is governed by kinetic factors instead of thermodynamic properties The dissolution rate is the amount of active substance that leaves the surface of drug and dissolved into the...

151
1,381
0

Database development and machine learning prediction of pharmaceutical agents

... pharmaceutical research and development This work on database development and machine learning prediction of pharmaceutical agents is one of such kind of strategy which is introduced in this chapter This ... Generally database development is a complicated and time-consuming process, including collection of related information, design of database scheme and data integration, design of database interface and ... screening of pharmaceutical agents 1.4 Classification of acute toxicity of pharmaceutical agents 16 1.5 Objectives and outline 18 Chapter Methods 20 2.1 Database...

Báo cáo y học: "A statistical method for predicting splice variants between two groups of samples using GeneChip® expression array data" pps

... detection of splice variants between two phenotypes, or two disease status, or two experimental stimuli In this paper, we propose an approach to predict splice variants between two groups of samples ... splicing variants reported in PubMed literature for ALCAM [14] Discussion We have developed a two- step approach to predict splice variants between two groups of samples using GeneChip® gene expression ... probe hybridization intensity between two groups of samples for each probe Then, for each gene, we merge probes into clusters based on the similarity of the differences in probe intensity (between...

Tài liệu Final report "The Situation of Learning English for Electrical Engineering of D06k52 Students in Faculty of Foreign Language, Ha Noi University of Technology" docx

... Ngoc D06K52 Faculty of Foreign Language Ha Noi University of Technology The Situation of Learning English for Electrical Engineering of D06k52 Students in Faculty of Foreign Language, Ha Noi University ... Bich Ngoc D06K52 Faculty of Foreign Language Ha Noi University of Technology Introduction This report discusses the situation of learning EEE of d06, k52 students in FOFL, HUT Before studying this ... Bich Ngoc D06K52 Faculty of Foreign Language Ha Noi University of Technology Results The course requirements in textbook of English for Electrical Engineering: Before the lesson - Students are...

Tài liệu Đề tài " Statistical properties of unimodal maps: the quadratic family " pptx

... Ξi (Ci ) ∩ Fκ then Ξi (Ci ) = Ji+1 [g] We will concentrate on the analysis of the regularity of Ξi for the special class of simple maps f : one of the good properties of the class of simple maps ... Sketch of the proof of the phase-parameter relation The proof of the phase-parameter relation uses ideas from complex analysis We will provide a sketch of the proof assuming familiarity with the ... to the validity of the Law of Large Numbers Are other theorems still valid, like the Central Limit or Large Deviation theorems? Those questions are usually related to the rates of mixing of the...

Tài liệu Báo cáo khoa học: Properties of ecdysteroid receptors from diverse insect species in a heterologous cell culture system – a basis for screening novel insecticidal candidates docx

... Effects of substituent on the aromatic moiety of dibenzoylhydrazines on larvicidal activity against the Colorado potato beetle Leptinotarsa decemlineata Pest Manag Sci 57, 85 8–8 65 Nakagawa Y, Minakuchi ... region and ligand-binding domain (LBD) of ecdysone receptors Fig S2 Amino acid alignment of linker region and ligand-binding domain (LBD) of ultraspiracle ⁄ RXR receptors This supplementary material ... normalized on the basis of b-galactosidase activity as a measure of cell mass For each agonist, fold inductions are shown relative to the normalized luciferase activity observed in the absence of...

Tài liệu Báo cáo khoa học: "Trimming CFG Parse Trees for Sentence Compression Using Machine Learning Approaches" pptx

... only original sentences are parsed, and the parse trees of compressed sentences are extracted from the original parse trees An example of this method is shown in Figure The original sentence is ... goal sentence length for summaries In the ﬁrst experiment, the system was given only a sentence and no sentence length information The sentence compression problem without the length information ... Noisy-Channel Model for Sentence Compression B D Knight and Marcu proposed a sentence compression method using a noisy-channel model (Knight and Marcu, 2000) This model assumes that a long sentence was...

Tài liệu Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1 doc

... response to vaccination against avian influenza in zoo-birds using an inactivated H5N9 vaccine Vaccine 2007, 25, 4345–4349 43 Robinson, J.H.; Easterday, B.C Avian influenza virus infection of ... national strategies for control of high-pathogenicity avian influenza and low-pathogenicity notifiable avian influenza in poultry, with emphasis on vaccines and vaccination Rev Sci Tech 2011, 30, 839–870 ... an insight into possible alternative approaches for control of AIV in poultry particularly against the HPAI H5N1 subtype Antivirals 2.1 Chemotherapy The use of chemotherapeutic agents for control...

Xem thêm

Từ khóa: 2—approaches for predicting service life of new concrete measurements of vaccinia virus dissemination using whole body imaging approaches for predicting of lethality in challenge models and testing of vaccines and antiviral treatments alternative econometric approaches for analyzing the role of the financial sector in economic growth the biological and pharmacological properties of cordyceps sinesis a traditional chinese medicine that has broad clinical applications immunological approaches for the modi cation of adenoviral tropism site directed mutagenesis for improving biophysical properties of vh domains maturation for the protective properties of the pellicle biological and pharmacological properties of viscum album l from tissue flask to man pharmacological properties of the active constituents of some traditional herbal antimalarials summary of procedures for evaluating larvicidal properties of plant derived products a probe for the elastic properties of films structure activity relationships for predicting ecological effects of chemicals 1—nondestructive test methods for determining material properties of hardened concrete in 2—nondestructive test methods for determining material properties of hardened concrete in existing construction aci 228 2 riós 2011 chemical constituents and pharmacological properties of poria cocos university of valencia spain pp 24 25 Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018 Báo cáo quy trình mua hàng CT CP Công Nghệ NPV Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt nam đề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giải Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Quản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninh Phối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọ Phát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninh Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùng Chuong 2 nhận dạng rui ro Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui ro Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015 MÔN TRUYỀN THÔNG MARKETING TÍCH HỢP TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ