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Regulatory mechanisms defining the blastocyst cell lineages

Regulatory mechanisms defining the blastocyst cell lineages

Regulatory mechanisms defining the blastocyst cell lineages

... enclosing the blastocyst cavity and the ICM By the late blastocyst, the PE appears as a distinct layer of cells on the surface of the ICM lining the cavity, with deeper cells comprising the pluripotent ... each other to allow for blastocyst cell lineages segregation 2.5 Stem cells from the blastocyst There have been three types of stem cells derived from the mouse blastocyst, representing the three ... embryonic part of the blastocyst and the other becomes the abembryonic part It also has been argued that the orientation of the first cleavage, implied to be marked by the position of the second polar...
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Defining the contours of cyclic nucleaotide mediated regulatory switches from prokaryotes to eukaryotes

Defining the contours of cyclic nucleaotide mediated regulatory switches from prokaryotes to eukaryotes

... inhibitors Cyclic nucleotide binding to the GAF domain induces structural changes, which are then transmitted to the associated effector domain Objectives One of the major puzzles in the field of ... R-subunit: structural insights into the mechanism of activation of PKA 2) To monitor the conformations of reaction intermediates and the role of CNB-B in the regulation of PKA using amide hydrogen/deuterium ... levels of expression of these isoforms leads to malignancy of cells (Cho-Chung and Nesterova, 2005) The expression and association pattern of these tissue specific isoforms are thought to be responsible...
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Defining the Date Field Component

Defining the Date Field Component

... Page with the Date Field Component ... CHAPTER s DEFINING THE DATE FIELD COMPONENT By adding the decode() method to the HtmlInputDateRenderer class, you can control the decode processing of the inputDate component To get the request ... DEFINING THE DATE FIELD COMPONENT and is rendered directly as the value in the markup When there is no submittedValue, then the type conversion to Date was successful, and the code behaves in the...
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Defining the Deck Component

Defining the Deck Component

... DEFINING THE DECK COMPONENT Requirements for the Deck Component The design of the deck component will allow a user to expose specific information that is currently hidden by clicking one of the ... HtmlShowOneDeck component to the page, and by giving the hidden form field the same name as the clientId of the HtmlShowOneDeck component, you ensure you expand the correct HtmlShowOneDeck component ... each component in the component hierarchy In the application, the only event fired during this request is the ShowEvent delivered by the UIShowOne component Renderer The UIShowOne component has the...
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Defining the project

Defining the project

... once the project is in its final stages It is very important to construct the project brief carefully because it is the basis for all further work on the Defining the project 55 project It is the ... decisions These can be referred to rather than repeated in the project brief and may be added as appendices There may be documents about the Defining the project 57 background to the project and the ... be the one who confirms that the project has been successfully completed The project team – these are the people who will carry out all of the tasks and activities to complete the project These...
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Tài liệu The Turner Review: A regulatory response to the global banking crisis pdf

Tài liệu The Turner Review: A regulatory response to the global banking crisis pdf

... profits And the market capitalisation of financial companies, and in particular banks, grew as a % of GDP and as a % of total market capitalisation (Exhibit 1.29) This growth appears to be at variance ... regulation – in the US, the UK and increasingly across the world – has been that financial markets are capable of being both efficient and rational and that a key goal of financial market regulation ... 1.12: Trading book assets & capital 2007: examples Market risk capital requirement as % trading assets Trading assets as % of total assets Trading / market risk capital as % total capital requirements...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Defining the Semantics of Verbal Modifiers in the Domain of Cooking Tasks" pptx

... operating in the domain of cooking tasks The primitive actions along with the timing information in the SEAFACT output are used to represent the range of verbal modifiers discussed in this paper The ... interpreted relative to their global context, in this case the cooking domain Values must be determined for each of the gradable terms, based on knowledge of typical values in the domain In the ... TotalTime The number of intervals present during the total time period is calculated by dividing the total time period by the sum of the length of one incident of the action and the length of a single...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf

... complex than the classical definition) The set of rules in a grammar forms a formal grammar, ie it defines a language, in fact two languages, one of strings and the other of trees At the moment, there ... the grammar formalism One also sees that the grammar is declarative in nature, and thus it is interpretable both for analysis and for generation (for example, by ~nterpretlng the rules as tree ... we have yet to speak of a grammar) ; for instance, the TREE in fig does not necessitate the presence of a rule of the form "AP NT hunter ~ NP" to be in the grammar The grammar formalism for such...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx

Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx

... destabilizing the double bond character of the pThr-Pro bond [26] Further evidence is available for the catalytic mechanism of Pin1 resembling more closely that of the other prolyl cis trans isomerases, ... about the molecular mechanisms of the enzyme action Most importantly, we want to critically review the evidence that Pin1 would or would not act as a prolyl cis trans isomerase Molecular mechanisms ... downstream of the proline could lead the WW domain to read the cis form in a reversed manner The initial screen for Pin1 substrates, which identified it as a phospho-dependent prolyl cis trans isomerase, ...
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Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx

Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx

... restriction to Lck accessing certain tyrosine residues of the protein chain Our studies have determined the efficiency of phosphorylation of each of the six f ITAM tyrosines by PTK Lck, from which ... vitro phosphorylation by Lck, confirmed tyrosine 1N to be the first phosphorylated Differences arising in the order of phosphorylation of the subsequent tyrosines in the whole cTCRf chain in vitro, ... rate-limited by ATP concentration The levels of incorporation of 32P into the peptide were used to calculate the kinetics of phosphorylation by Lck at each tyrosine, and from these an order of phosphorylation...
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Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc

Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc

... description of regulation of the G1-S transition of the mammalian cell cycle Biotechnol Bioeng 65, 631–637 Aguda B & Tang Y (1999) The kinetic origins of the restriction point in the mammalian cell cycle ... the correlation plot and the gradient of cyclin E/Cdk2:p27 was close to the value of the co -control coefficient of the intermediate with cyclin E/Cdk2:p27 For example, the gradient ratio for cyclin ... 2009 The Authors Journal compilation ª 2009 FEBS R Conradie et al A Restriction point control of the mammalian cell cycle C B D E F Fig The reaction network scheme of the mammalian cell cycle...
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Báo cáo khoa học: PA700, the regulatory complex of the 26S proteasome, interferes with a-synuclein assembly pptx

Báo cáo khoa học: PA700, the regulatory complex of the 26S proteasome, interferes with a-synuclein assembly pptx

... behavior of WT a-synuclein in the absence and the presence of PA700 Aliquots of WT a-synuclein assembly reactions in the absence (–) or the presence (+) of PA700, h and 18 h after the onset of the assembly ... proteins The base consists of six ATPases that belong to the [15] The functions proposed for the ATPases include: (a) the hydrolysis of ATP to promote the assembly of the 26S proteasome from the PA700 ... In the absence of PA700, WT a-synuclein emerges from the column in a single peak centered at 300 kDa In the presence of PA700, WT a-synuclein emerges from the column with a molecular mass of...
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Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx

Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx

... of phosphorylation rate seen at the concentration x of H4biopterin vo is the rate in the absence of H4biopterin and vmin is the rate at very high concentrations of H4biopterin The observed Hill ... H4biopterin, the oxidized cofactor H2biopterin and the catecholamine inhibitor dopamine From Fig 3A it is seen that on preincubation with saturating concentrations (Fig 3B) of the biopterin cofactors ... binding changes the position and orientation (relative to the catalytic iron) and the hydrogenbonding network of the bound H4biopterin Moreover, the substrate induced repositioning of the cofactor also...
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Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx

Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx

... of hCdc6p However, more importantly in the present context, we note that the synthesis of hCdc6p continues through most of the cell cycle Synthesis of hCdc6p during G1 phase is necessary for the ... that about one half of the newly synthesized hCdc6p associated with chromatin during the 2-h label period Rates of hCdc6p synthesis To investigate whether the synthesis of hCdc6p was restricted ... followed by the synthesis of new Cdc6p [28] Thus, synthesis follows degradation in early G1 phases whereas the production of new hCdc6p seems to occur simultaneously with the displacement of old hCdc6p...
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Commercializing the stem cell sciences pot

Commercializing the stem cell sciences pot

... 1.2  Emerging stem cell therapies and the commercialization of biotechnology On the one hand, the stem cell sciences are clearly part of the biotech industry Most obviously, stem cells are biological ... influencing the future shape of the stem cell market 1.4.2 The relationship between risk and return The other major factor limiting the potential success of emerging stem cell companies is the relationship ... commercialization in the stem cell sciences While the above list suggests a potentially unlimited commercial possibility for stem cell products, there are two core limitations that set the outer limits These...
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