Design and synthesis of cysmethynil and analogues as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)

... Wang M, Casey PJ Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) v TABLE OF CONTENTS ACKNOWLEDGEMENT .ii CONFERENCES AND PUBLICATIONS ... Analogues of cysmethynil demonstrate improved isoprenylcysteine carboxyl methyltransferase (Icmt) inhibition activity and antiproliferative activity in PC3 prostate cancer and MDA-MB-231 breast ... Gorla SK, Go ML, Wang M, Casey PJ Analogues of the Isoprenylcysteine Carboxylmethyltransferase Inhibitor Cysmethynil With Improved Antiproliferative Activity Against Breast and Prostate Cancer Cells...

Báo cáo Y học: Synthesis of phosphoenol pyruvate (PEP) analogues and evaluation as inhibitors of PEP-utilizing enzymes pot

... kinase and mM MgCl2 or 0.05 UÆmL)1 of pyruvate kinase and mM MnCl2 PEP carboxylase activity was determined in a coupled assay with malate dehydrogenase, as described previously [30] The rate of ... transiently phosphorylated in the course of the catalytic cycle, for instance, the activesite histidines of enzyme I of the PTS [2], phosphoenolpyruvate synthase, and pyruvate phosphate dikinase, ... kinase/L-lactate dehydrogenase assay Obviously, this methodology was not applied with compounds 1b–e (also 1f and 2f when Mn2+ was present) as they are good inhibitors of pyruvate kinase In these cases the...

Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt

... ATGGCGCCATTTTTCTTGAGACATGCC-3¢; reverse, 5¢-CTGGGATCCGTCCGAATCAGGTTCCTTC-3¢ (purchased from Sigma), and the pKK plasmid as a template [32] The resulting fragment was cloned into NcoI and BamHI sites of the ... Suv3(D1-159) and WNV NTPase/helicases The NTPase/helicase domain of HCV NS3 was expressed in E coli and puriﬁed as described previously [30], with certain modiﬁcations The bacteria were collected by centrifugation ... Inhibition of NTPase/helicase activities of hepatitis C (Eur J Biochem 270) 1651 Fig Comparison of ATP binding in HCV NS3 helicase and protein kinase CK2 (A) Ribbon diagram of HCV NS3 helicase complexed...

Báo cáo hóa học: " One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels" doc

... doi:10.1007/s11671-010-9774-z Cite this article as: Zhai et al.: One-Pot Synthesis of Biocompatible CdSe/CdS Quantum Dots and Their Applications as Fluorescent Biological Labels Nanoscale Res Lett 2011 ... temperature, and 19 mg of Se powder was added Finally, the mixture was heated to 240°C and kept for a certain period of time such as 1, 5, 60, and 120 Synthesis of CdSe/CdS QDs As sulfur source, ... monochromaticity of the fluorescence but also the quantum yields of the QDs In our case, the quantum yields of the as- synthesized CdSe cores are around 2–3% In order to passivate their surface trap sites and...

identification, design and synthesis of oxygenated hydrocarbon-based carbon dioxide-soluble polymers for chemical and petroleum engineering applications

... ABSTRACT IDENTIFICATION, DESIGN AND SYNTHESIS OF OXYGENATED HYDROCARBON-BASED CO2-SOLUBLE POLYMERS FOR CHEMICAL AND PETROLEUM ENGINEERING APPLICATIONS Lei Hong, Ph.D University of Pittsburgh, 2006 ... defended on March 29, 2006 and approved by Dr Eric J Beckman, Professor, Chemical and Petroleum Engineering Department Dr J Karl Johnson, Professor, Chemical and Petroleum Engineering Department ... Professor, Department of Chemistry Dissertation Director: Dr Robert M Enick, Chairman and Professor, Chemical and Petroleum Engineering Department ii Copyright © by Lei Hong 2006 iii ABSTRACT IDENTIFICATION,...

Green synthesis of copper nanoparticles colloidal solutions and used as pink disease treatment drug for rubber tree

... average size of copper nanoparticles was about 6nm via TEM images This colloidal solution was used as anti Pink Disease drug for rubber tree at low concentration (dose of resistance fungus of about ... method This colloidal solution was used as anti Pink Disease drug for rubber tree at low concentration (dose of resistance fungus of about 5-7ppm (Fig.6) and dose of kill fungus of about 10ppm ... stable for over months The stabilization of copper colloidal solutions were due to the capping of nanoparticles by PVP 55,000 in reaction process The 5th sample were testing to treatment Pink disease...

Design and synthesis of stimuli responsive polymer based nanoparticles

... of stimuli- responsive polymers are temperature -responsive polymers and pH -responsive polymers Other types of stimuli- responsive polymers, such as light -responsive polymers, field -responsive polymers ... methodologies for synthesis of stimuli- responsive polymers and the techniques for preparation of smart polymer based nanoparticles In Chapter 3, well-defined comb-like graft copolymers, consisting of a fluorescent ... images of the self-assembled hollow nanoparticles of the KVND copolymer of Table 3.1 in aqueous media: (a) pH and 25 oC, (b) pH and 25 oC and (c) pH and 40 oC The concentration of the copolymer...

Design and synthesis of functional graphene composites and their applications

... DESIGN AND SYNTHESIS OF FUNCTIONAL GRAPHENE COMPOSITES AND THEIR APPLICATIONS JANARDHAN BALAPANURU M.Sc., University of Pune, India A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... bond of graphene and (b) formation of bond between organic functional groups and oxygenated-groups of GO (a) Addition of free radicals to sp2-carbon of graphene: Upon heating the mixture of diazonium ... functional graphene composites for various applications In this thesis, the design and synthesis of various graphene- based composites and their potential applications have been discussed with regards...

Synthesis of metal oxide nanostructures and their applications as lithium ion battery anodes

... IONP@PC and IONP@mC-600 Insets of C and F: SAED patterns of IONP@PC and IONP@mC-600 95 Figure 6-4: Particle size distributions of (A) IONP@PC and (B) IONP@mC-600 96 Figure 6-5 TEM images of IONP@mC-600 ... iron oxides and lithium was in the 1980s.[51] However, the nature of the reaction was not clear until J M Tarascon and his coworkers reported the conversion reaction between transition metal oxides ... as TiO2[30] and Li4Ti5O12[17]; (2) alloying based materials, such as Si,[31] Ge,[32] Sn,[33] and their oxides/composites; (3) conversion reaction based materials, including transition metal oxides,[34]...

188
1,022
0

Design and synthesis of donor acceptor hybridized small molecules and graphene derivatives for photovoltaic and optical studies

... DESIGN AND SYNTHESIS OF DONOR ACCEPTOR HYBRIDIZED SMALL MOLECULES AND GRAPHENE DERIVATIVES FOR PHOTOVOLTAIC AND OPTICAL STUDIES ANUPAM MIDYA M.Sc (Chemistry), ... the interface of the donor and acceptor material and split into hole and electron For efficient charge separation, the HOMO and LUMO energy levels of p-type (Donor) and n-type (Acceptor) materials ... and formation of bonds (a) for two sp2 -hybridized carbon atoms Figure 1.2 A schematic diagram of energy levels, hybridization of atomic orbitals creates two continuous band states of filled and...

Synthesis of crown ether and cyclam capped beta cyclodextrin bonded silica particles and their application as chiral stationary phases in liquid chromatography

... the Synthesis of Bonded Chiral Stationary Phases for Liquid Chromatography 1.3.1 Types of Chiral Stationary Phases for Liquid Chromatography 1.3.2 Preparation of β -Cyclodextrin Type of Chiral Stationary ... with Crown Ether- capped β-CD -bonded Phases and Cyclam- capped β-CDbonded Phases 124 5.4 Concluding Remarks 128 5.5 References 129 CHAPTER APPLICATION OF CROWN ETHER- CAPPED CYCLODEXTRIN- BONDED PARTICLES ... bromide, and finally reacted with several kinds of amine-containing crown ethers and cyclams to form new types of crown ether/ cylcam -capped β-CDbonded phases [102,103] It is found that crown ether/ cyclam- capped...

Design and synthesis of novel metal complex protein conjugation agents for applications in bio imaging

... Design and Synthesis of novel metal complex- protein conjugation agents for Applications in bio- imaging WANG TAO (BSc, Sichuan University2008 ) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... Modification of Proteins There is an increasing interest in protein conjugates for diagnosis and therapy Even though proteins often display limited pharmacokinetics, low proteolytic stabilities and the ... Design of biocompatible metal- complex protein conjugates In order to design biocompatible metal- complex protein conjugates which can achieveprecise intracellular delivery and improved sensitivity for...

The Design and Implementation of a Log-Structured File System

... purpose The separate data area of these database systems means that they not need the segment cleaning mechanisms of the Sprite LFS to reclaim log space The space occupied by the log in a database system ... log as the most up to date ‘‘truth’’ about the state of the data on disk The main difference is that database systems not use the log as the ﬁnal repository for data: a separate data area is reserved ... has the disadvantage of increasing the amount of data lost during a crash For this paper we will assume that crashes are infrequent and that it is acceptable to lose a few seconds or minutes of...

15
1,434
0

Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"

... orally [27] Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 and hSGLT2 as a potential therapeutic ... O-glucosides involved in the biosynthesis of chrysomelidial and salicin These substances are synthesized and secreted as part of a defense mechanism used by larvae of beetles (Chrysomelidae) Their synthesis ... synthesis has been previously described [31-33] For the purpose of the present study the thioglycosides used were selected and grouped based on their differences in the aglycone binding site or in the...

Design and development of major balance of plant components in solid oxide fuel cell system

... determining the SOFC system performance The detailed designs of each of these components in the INER SOFC system are described in the following subsections 3.1 Flow distributor In general, an SOFC ... 44%) Design of SOFC BOP components The BOP components of a SOFC system account for between 50% and 70% of the total system cost Due to the high operating temperature of SOFC, the material of all ... pressure and mass flow rate in the major BOP components so as to identify potential design improvements in the INER SOFC system in the future In practice, optimizing the SOFC system performance using...

Xem thêm

Từ khóa: the design and development of imidazothiazolechalcone derivatives as potential anticancer drugs digital logic design and synthesis of combinational and sequential circuits pdf such as the planning and use of observations interviews and document reviews to assess facility performance and contractor design and construction activities report results and follow up on actions taken as the result of assessments design development and synthesis of novel cephalosporin group of antibiotics chemical synthesis of lipid a and analogues design and synthesis of enzyme mimics of beta carotene 15 15 apos monooxygenase the design and implementation of public works programs support the design and development of an information system on the design and development of program families the design and development of the design and development of pegfilgrastim pegrmethugcsf neulasta the design and development of pegfilgrastim the design and development of a solar powered refrigerator api 2510 design and construction of lpg installations design and construction of lpg installations Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thống chuyên đề điện xoay chiều theo dạng Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt nam Nghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoại Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THz Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Giáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôit Quản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninh Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hương Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIX Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)MÔN TRUYỀN THÔNG MARKETING TÍCH HỢP QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ