... impact on survival [6] In particular, agitation impedes patient cooperation during weaning from mechanical ventilation and very often leads to delayed extubation Undue prolongation of mechanical ... effect on anxiety and the observed decrease in respiratory rate This study is a preliminary physiological evaluation of the acute, short-term effects and safety of loxapine during weaning from mechanical ... agitation before agitation Figure Values for three sedation /agitation scores before agitation, at the time of agitation, and at 60, 90, 120, and 180 minutes after loxapine (LXP) administration...