... human salivary gland cancer cells Oral Oncol 2006, 42:593598 44 Hayashi M, Sakata M, Takeda T, Tahara M, Yamamoto T, Okamoto Y, Minekawa R, Isobe A, Ohmichi M, Tasaka K, Murata Y: Up-regulation ... normal tissues and for tackling ‘undruggable’ targets Technological advances, coupled with the availability of large siRNA and shRNA libraries, now make unbiased synthetic lethal screens in mammalian ... 99.2 (a) (b) Gene A Gene A mutation Normal cell Gene B A B Viable A b B Viable a b A B B Viable a Cancer cell Lethal Inhibitor of B A Viable Dead Figure Synthetic lethality (a) Table showing the...