Role of promyelocytic leukemia (PML) and small ubiquitin like modifier (SUMO) proteins in alternative lengthening of telomeres
Role of promyelocytic leukemia (PML) and small ubiquitin like modifier (SUMO) proteins in alternative lengthening of telomeres
... modifications of a protein may also involve the attachment of other proteins or peptides, such as ubiquitin and the small ubiquitin- like modifier (SUMO) Subsets of a pool of proteins may be modified ... according to the cellular conditions and microenvironment as part of the cellular response and regulatory processes 1.1.1 Small Ubiquitin- like Modifier (SUMO) The Small Ubiquitin- like Modifier (SUMO) ... the RING domain Both bind zinc but differed in terms of the number and spacing of conserved Cys and His ligands (Borden et al 1996) While substitution of the conserved zinc ligands in B1 and/ or...
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Antiproliferative activity of curcumin analogs on acute promyelocytic leukemia synthesis and mode of action studies
... depending on the differentiation direction and degree of maturation 1.2 Acute Promyelocytic Leukemia (APL) Acute promyelocytic leukemia (APL) accounts for 10 – 15 % of acute myeloid leukemia (AML) and ... 3.3.2 Anti-proliferative activity of curcumin and analogs on leukemic non-APL cell lines 91 3.3.3 Anti-proliferative activity of curcumin and analogs on human nonmalignant cell lines ... ring Several of these analogs demonstrated potent growth inhibitory activities on cancer cells 73, 79, 80 Figure 1-10: Monocarbonyl cross-conjugated dienone analogs of curcumin One of best known...
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Báo cáo khoa học: Meiosis and small ubiquitin-related modifier (SUMO)conjugating enzyme, Ubc9 potx
... CcTopII, CcPCNA and CcUbc9 are all present at meiotic prophase in Meiosis and Ubc9 C cinereus and that each of CcLim15, CcTopII, CcPCNA and CcRad51 has the potential to interact with CcUbc9 Moreover, ... in meiosis In C cinereus, however, because CcPCNA and CcUbc9 exist together in meiotic nuclei, 3526 the interaction between CcPCNA and CcUbc9 and sumoylation may occur at a certain point of meiosis ... amino acid and X is any amino acid [103,105] Therefore, complexes of Ubc9 Lim15 ⁄ Dmc1, Ubc9 TopII and Ubc9 PCNA may be intermediates in the production of SUMO–Lim15 ⁄ Dmc1, SUMO–TopII and SUMO–...
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báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx
... and network- based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression Rotem Ben-Hamo1 and Sol Efroni1,* The Mina and Everard ... over pathway behavior and may serve as a potential therapeutic target for Glioblastoma patients Drug target analysis Over the past 25 years and despite vigorous basic and clinical studies, the ... Pathway network interactions dataset: Network information was obtained from the National Cancer Institute's Pathway Interaction Database [12] Gene-expression analysis Pathway Consistency and Pathway...
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Báo cáo y học: "Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection" potx
... specificity of anti -HCV antibody responses in patients suffering from chronic HCV infection The specificity of anti -HCV antibody responses in patients suffering from chronic HCV infection A The ... using recombinant HCV core, NS3, NS4B or NS5A proteins, which represent the major immunogenic proteins of HCV (see below) There was some faint staining in 11 HCV- negative samples against certain ... antibodies against individual HCV proteins in human sera obtained from patients suffering from chronic HCV infection Clearly the core, NS3, NS4B and NS5A represented the major antigenic proteins By Western...
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Báo cáo y học: "Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice" ppsx
... plasma cytokines after flagellin administration Cytokines were quantified by ELISA in plasma at baseline (time 0), at one, three and six hours after μg flagellin, and at one and three hours after ... expressed in mouse organs in vivo, that flagellin elicits prototypical innate immune responses in these organs, and that it also activates apoptotic signaling, predominantly in the intestine These findings ... well as the production of multiple inflammatory cytokines, and also that flagellin initiates proapoptotic responses predominantly in the intestine Thus, flagellin/ TLR5 signaling elicits several...
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The Role of Small and Large Businesses in Economic Development doc
... innovation Small firms are the great innovators in some industries, while large firms are the great innovators in others Moreover, small and large businesses interact in innovative activity The ... businesses There is no clear evidence that small businesses are more effective innovators Further, the innovations of both small businesses and large businesses are inextricably linked Still, small ... analysis evaluated the economic development role of small businesses vis-à-vis large businesses It suggests that small businesses may not be quite the fountainhead of job creation they are purported...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... activity of HL-60 Cells Utilizing the induced differentiation of HL-60 promyelocytic leukemia cells as a model of myeloid maturation, we examined the expression and location of Rac and PAK The interaction ... cells induced with ATRA Induction of Rac and PAK HL-60 cells were treated with lM ATRA for a week, and Rac and PAK were assayed in both cytosol and membrane fractions Rac occurs as two isoforms (Rac1 ... Immunoblot analysis of Rac in the cytosolic and membrane fractions of HL-60 cells The differentiation of the cells were induced with lM ATRA for 0, 1, 3, and days (lane 0–7) and lane N indicates human...
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Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... activation of Aur-A and induces monopolar spindle in NB4-R2 cells (A) VX-680 inhibited phosphorylation of AurA at Thr288 in NB4-R2 cell line Cells were incubated with increasing doses of VX-680 ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In the present study, phosphorylation of Akt-1 and GSK3b, the downstream of Akt-1, ...
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báo cáo hóa học:" Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Journal of Translational ... proliferation of leukemic cells in AML and inhibition of activation of Akt can result in suppression of cell growth [40,41] In the present study, phosphorylation of Akt-1 and GSK3b, the downstream of Akt-1, ... decreases pAur-A at the activation site and induces monopolar spindle in NB4-R2 cells We studied the inhibition of Aurora kinases in NB4-R2 cells using VX-680 Aur-A activation was inhibited by VX-680...
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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx
... that p 21/ waf1 and cyclin D2 are complexed together in HTLV -1 infected cells Cell cycle analysis of cyclin D2 and p 21/ waf1 p 21/ waf1 has been previously described as an assembly factor for cyclin ... Cyc D2 CDK2 + CycE + p 21/ waf1 (WT, 10 0ng) D) CDK4 + Cyc D2 CDK2 + CycE B) CDK4 + CycD2 + p16/INK4A CDK4 + CycD2 + p 21/ waf1 (mut) CDK4 + CycD2 + p 21/ waf1 (WT) CDK4 + CycD2 Cyc D2 Cyc D2 P16/INK4A ... bands plexed with p 21/ waf1 and cyclin D2 in C 81 cells at hours The lack of cdk4 in p 21/ waf1 /cyclin D2 complexes in C 81 cells at hours and CEM cells at and hours may explain the observed loss of...
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The Position and role of small and medium enterprises in a national economy – the case of Japan
... Shizuoka and the lower rank three: Okinawa, Miyazaki and Nagasaki Japan consists of 47 prefectures) by using statistical data on the size of the enterprise and prefectural income (typical index that ... The Ministry of Health, Labour and Welfare) This means that SMEs have played an important and constant role in employment and have a significant role in social issues Japan is often called The ... reached a peak of 319,716 companies but the numbers have been declining since then In the latter half of the 1960’s, a comparatively remarkable increase in the number of SMEs with a capital scale of...
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Role of the survival proteins hsp27 and survivin in a small molecule sensitization to TRAIL mediated apoptosis 1
... cleaving lamins [39] and membrane blebbing by targeting proteins such as Rho-associated kinase (ROCK1), p- 21 activated kinase (PAK) and gelsolin [40-42] 1. 2 .1. 2 Inhibitors of apoptosis The IAP ... DISC [11 8] and results in the autocatalytic activation of the initiator caspases [11 9] in accordance with the induced proximity model Activated caspase-8/ -10 in turn targets the effector caspase-3 ... domains [11 5] Alternatively, ligation of TNF-! to TNF-R1 leads to the recruitment of the TNF-R1 Associated Death Domain protein (TRADD) [11 6] TRADD can then recruit FADD Acting as an adaptor...
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Role of the survival proteins hsp27 and survivin in a small molecule sensitization to TRAIL mediated apoptosis 2
... mitochondrial staining (A) Corresponding histogram of the mitochondrial aggregation (B) n =2 90 LY30 and TRAIL treatment engages the mitochondrial apoptotic pathway The release of apoptogenic factors ... treatment alone was unable to induce the activation of any of the caspases investigated and exposure of HeLa cells to LY30 resulted in minimal caspase activation (less than fold increase) after 6h and ... and Hoescht before analysis by Laser Scanning Cytometry Scattergram representing the area covered by mitochondria against the ratio of the highest mitochondrial staining intensity to the total...
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Từ khóa: ask and answer what your partner like and doesn t like use the pictures in 2role of small and medium enterprises in pakistanrole of small and medium enterprises development agency of nigeriathe role of small and medium size enterprises in cameroonstructure competition and the role of small businessinos in regulation of nitric oxide no production and stabilization of hif 1 potential role of se methylselenocysteine msc an antioxidant multi targeted small moleculeon the role of context and prosodythe role of the courts in patent law and policythe role of communication in business relationships and networkscompetition and the role of dominant antsthe role of termites and ants in soil modificationthe role of ants in conservation monitoring if when and howthe role of language and communication in conflict managementdiseases of the stomach and small intestinethe role of energy in the body health and social careNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ