Unraveling genomic instability in multiple myeloma mechanisms, biological and clinical implications
Unraveling genomic instability in multiple myeloma mechanisms, biological and clinical implications
... underlying this is unclear Genomic instability in cancer is broadly categorized into mutational instability, e.g., microsatellite instability (MIN) and chromosome instability (CIN) CIN, characterized ... 13% of patients In addition inactivating mutations of TRAF2, cIAP1/2, and CYLD were identified Chromosome translocations and amplifications resulting in activation of NFB inducing kinase (NIK) (Annunziata, ... activation in the remaining patients 1.2.5 Dysregulation of a Cyclin D gene: A unifying and early oncogenic event in MGUS and MM It has been proposed that dysregulation of a Cyclin D gene is a unifying,...
- 207
- 232
- 0
Báo cáo y học: "Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications" doc
... understanding of MetS The insulin receptor has an intrinsic tyrosine kinase activity Binding of insulin to its receptor induces both autophosphorylation and phosphorylation of tyrosine residues on insulin ... the insulin receptor and/ or IRS proteins, whereas the MAP kinase pathway remains open and may even be hypersensitive [10] Inflammatory cytokines and insulin resistance Inflammatory cytokines ... Pathophysiology: complementary roles of insulin resistance and abdominal obesity Insulin signaling Since insulin resistance is a key feature of this syndrome, a brief overview of insulin signaling...
- 9
- 310
- 0
Báo cáo y học: "Clinical review: Sleep measurement in critical care patients: research and clinical implications" pdf
... Relatively easy to incorporate into routine nursing care Attempts to qualify wake, non-rapid eye movement, and rapid eye movement sleep Advantages Summary of methods used in critical care for sleep measurement ... those pertaining to sleep measurement in adult patients during their critical care admission and published in full in English Study comparing different sleep measurement techniques In the context ... hallucinations, psychosis and REM sleep in GuillainBarre syndrome Brain 2005, 128:2535-2545 32 Hardin KA, Seyal M, Stewart T, Bonekat HW: Sleep in critically ill chemically paralyzed patients requiring mechanical...
- 17
- 361
- 0
báo cáo khoa học: " Response to dexamethasone is glucose-sensitive in multiple myeloma cell lines" pps
... DEX and this action seems mainly involving pathways regulating ROS in MM cells Whether this finding will help in reducing DEX toxicity or improving its efficacy particularly in combination with ... leukemic cells and primary thymocytes [13] We show that TXNIP-ROS-TRX axis is functional in response to glucose in out of MM cell lines tested and TXNIP RNA level is responsive to DEX in the same cell ... Davis MC, Zhong F, Distelhorst CW: Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis Oncogene 2006,...
- 7
- 229
- 0
Activities of the cytokine receptor CD137 in multiple myeloma
... Bidirectional Signalling of the CD137: CD137L System 16 1.9 CD137/ CD137L in Tumor Immunotherapy 19 1.10 Multiple Myeloma and the CD137: CD137L System 23 1.11 Multiple Myeloma and Follicular ... rendering it obsolete Published by the International Myeloma Working Group in 2005, the International Staging System (ISS) for multiple myeloma relies mainly on the detection of levels of albumin ... OBJECTIVES OF STUDY The specific objectives of this study are: a to investigate the expression of CD137/ CD137L on multiple myeloma cells b to characterize the inhibitory effects of CD137 on multiple myeloma...
- 120
- 340
- 0
recent advances in wide bandgap semiconductor biological and gas sensors
... detection in gases and liquids, flue gas and fire detection, liquid quality sensors, biosensors and medical sensors Some of the major applications in the home include indoor air quality and natural gas ... available hand-held wireless transmitter to realize a portable, fast and high sensitive CO2 sensor 2.4 CH4 sensing Of particular interest in developing wide bandgap sensors are methods for detecting ... metabolites and markers, and this can be valuable in measuring both medication adherence and in determining the blood levels of these drugs and medications Some of today’s blood and urine-based...
- 59
- 574
- 0
Báo cáo hóa học: " Multipattern Consensus Regions in Multiple Aligned Protein Sequences and Their Segmentation" pot
... evaluating consensus regions in multiple aligned protein sequences This paper presents an outline of the segmentation algorithm (see Yan [10]) for multipattern consensus regions in aligned protein sequences, ... overlapping regions Gap exists between some regions The result shows that the positions of the p53 sequences form clear regions There are D -regions, I -regions, and V -regions The D -regions and the V -regions ... and V -regions (sites 162–174, 232–236) in the p53 core domain (sites 94 − −289) The sequences from the D -regions are shown in Figure The interdependency of the amino acids among the first 21 sequences, ...
- 8
- 172
- 0
Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx
... fragments Noncollagen and nonaggrecan proteins Cartilage oligomeric matrix protein Type I collagen Pyridinoline, deoxypyridinolin PYD, DPD Type I collagen C-terminal and N-terminal telopeptides CTX-I, ... Activity Index (reviewed in [9]) – have been shown useful for following disease activity and for serving as endpoints in clinical trials and observational studies [72,73] Moreover, disease activity ... function, including proteins involved in the Wnt signaling pathways [85], may therefore constitute further interesting markers for the future Importantly, however, achieving low disease activity or...
- 12
- 379
- 0
Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
... of a variety of models, including CIA and several murine lupus models Clinical trials directly targeting IL-21 are in pre -clinical planning at this time The therapeutic utility of this cytokine ... presentation by Novartis at the ACR Annual Scientific Meeting 2008) The results of other ongoing clinical trials targeting IL-17 will certainly increase our understanding of the role of this cytokine in ... suggesting a role for IL-33-mediated mast cell activation in joint inflammation Indeed, the administration of sST2 decreased the production of inflammatory cytokines and the severity of collagen-induced...
- 14
- 467
- 0
báo cáo khoa học: "Multiple Myeloma Involving Skin and Pulmonary Parenchyma after Autologous Stem Cell Transplantation" potx
... relapsed disease after autologous stem cell transplantation The presence of circulating plasma cells and hyperammonemia are both known to be indicators of advanced disease Plasma cell neoplasm should ... M, Hanafusa T: Pulmonary parenchymal infiltrates in a patient with CD20-positive multiple myeloma European Journal of Haematology 74:61-65 Freeman Z: Myelomatosis with extensive pulmonary involvement ... J, Rosenow E, Kyle R: Thoracic and Pulmonary Abnormalities in Multiple Myeloma Archives of Internal Medicine 1978, 138:727-730 Chejfec G, Natarelli J, Gould V: Myeloma lung: a previously unreported...
- 2
- 176
- 0
Domestic Trends in the United States, China, and Iran - Implications for U.S. Navy Strategic Planning pdf
... W74V8H-06-C-0002 Library of Congress Cataloging -in- Publication Data How domestic trends in the U.S., China, and Iran could influence U.S Navy strategic planning / John Gordon IV [et al.] p cm Includes ... trends in the United States, the People’s Republic of China (PRC), and Iran The Navy is interested in these countries’ likely “resource drivers” from Domestic Trends in the United States, China, ... standards for research quality and objectivity Domestic Trends in the United States, China, and Iran Implications for U.S Navy Strategic Planning John Gordon IV, Robert W Button, Karla J Cunningham,...
- 234
- 414
- 0
Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... domain Because WD40 domain is involved in mediating protein–protein interactions, the LRRK2 G2385R variant may impact on interactions with substrates and ⁄ or regulatory proteins Preliminary studies ... Genetic and clinical studies of LRRK2 U Kumari and E K Tan cal hallmarks are characterized by a progressive and profound loss of neuromelanin-containing dopaminergic neurons in the substantia ... (2007) Comparing knowledge and attitudes towards genetic testing in Parkinson’s disease in an Genetic and clinical studies of LRRK2 American and Asian population J Neurol Sci 252, 113– 120 56...
- 9
- 490
- 0
Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... arthritis may be induced by systemic autoreactivity remains interesting and plausible G6PIinduced arthritis provides a model in which both the induction and modulation of arthritis induced by autoreactivity ... autoreactivity against the ubiquitously expressed glycolytic enzyme G6PI specifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune disease Interestingly, although ... the development of arthritis in the K/B×N model are involved in human RA Both experimental and clinical data strongly support the possibility that autoreactivity against systemically expressed autoantigens...
- 9
- 419
- 0
Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ