Distribution and role of calcium independent phospholipase a2 in the brain

... is the cessation of blood flow to the brain and disruption of metabolic demand During early stages of ischemia (within min), inositolcontaining glycerophospholipids are the main source of the increase ... define the physiological role of sPLA2 and ascertain its contribution in the inflammatory process 1.2 cPLA2 isoforms The cPLA2 family consists of six intracellular enzymes, cPLA2α, cPLA2β, cPLA2γ, ... class of phospholipase A2 (PLA2) that does not require calcium for its activity is the cytosolic calcium- independent PLA2 (iPLA2) In brain tissues, the basal expression and activity of iPLA2 is...

FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE

... sometimes 2.1 Orofacial pain Orofacial pain is defined as pain within the structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders ... revealed that pain is one of the main reasons that patients look for medical attention and that the lifetime prevalence of pain indications such as back pain, chest pain, headache and joint pain is around ... neuropathic pain in mice, further highlighting the involvement of DHA and its metabolites in mediating neuroinflammation and pain (Yacoubian and Serhan, 2007; Nakamoto et al., 2010; Xu et al., 2013) Pain...

Tài liệu Báo cáo khoa học: Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells pptx

... iPLA2-VIA mediates U937 cell proliferation M A Balboa et al cPLA2 activity (% hydrolysis) A 0.0 0.2 0.4 0.6 0.8 1.0 [Pyrrophenone] (µM) B Number of cells × 105 iPLA2-VIA by treatment of cells ... the Ca2+dependent PLA2 activity of U937 cell homogenates The cell membrane assay was utilized (B) Time course of the effect of pyrrophenone on the proliferative capacity of U937 cells The cells ... involvement of iPLA2, but not cPLA2a, in U937 cell proliferation Owing to the lack of speciﬁcity of BEL in cell-based assays [28], additional pharmacological evidence for the involvement of iPLA2 in U937...

Báo cáo khoa học: Calcium-independent phospholipase A2-mediated formation of 1,2-diarachidonoyl-glycerophosphoinositol in monocytes potx

... increased rate of arachidonatephospholipid remodeling Lack of involvement of group IV and group VI phospholipase A2 in remodeling and increased susceptibility of proliferating T cells to CoA-independent ... concentrations that involves the direct acylation of both the sn-1 and sn-2 positions of PtdIns 1,2-Diarachidonoyl-glycerophosphoinositol Results Initial incorporation of [2H]AA into PtdIns When monocyte ... incorporation of exogenous [2H]AA into PtdIns To directly study the role of deacylation–reacylation reactions in the incorporation of AA into PtdIns, we conducted experiments in the presence of the...

Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their ... by insulin Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation...

báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx

... the decision of continuing the ongoing therapy or stopping and redirecting the patient to other salvage therapies Our study also supports the idea of routine use of PET or preferably PET/CT in ... and serial imaging tests The subjects were divided into three groups 4/42 of the analysed scans were performed for preoperative staging (group 1), 30/42 of the for posttherapy restaging (Group ... on spiral CT The superiority of PET/CT, a metabolic imaging tool, over CT in the preoperative N staging is marked in this case In the literature, although PET/CT does not have a role in T staging...

Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"

... attack (15) The present clinical trial evaluated the safety and efficacy of UC -II in the treatment of the knee in OA patients Materials and Methods Study Design This clinical trial (Human Clinical ... Compliance was assessed by capsule count at visits 3, 4, and and review of subject diary Efficacy and Safety Variables Efficacy and safety measurements assessed Adverse events During the study, ... 28(4):385-90 D'Altilio M, Peal A, Alvey M, Simms C, Curtsinger A, Gupta RC, Canerdy TD, Goad J, Bagchi M, Bagchi D Therapeutic efficacy and safety of undenatured type II collagen singly or in combination...

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... conﬁrmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts as an activating element binding ... responsible for cell cycle-dependent expression of the gene Surprisingly, deregulation of the promoter does not lead to loss of its activity but causes activation in resting cells and in G1 cells Therefore,...

Tài liệu PRINCIPLES AND PRACTICES OF ORGANIC LETTUCE SEED PRODUCTION IN THE PACIFIC NORTHWEST potx

... extreme heat during flowering can damage the seed Rain during harvest can cause seed shattering, sprouting of seeds in the seed heads, and encourage discoloration and diseases of the seed Higher ... Romaine lettuce   Growing Lettuce Seed The majority of the lettuce seed produced in the United States comes from the coastal valleys of California In the Pacific Northwest, lettuce seed has historically ... emergence, the lettuce is thinned within rows to the final spacing of 12 – 1 6in (30 – 40cm) Transplanted lettuce would be spaced at the final spacing of 12 – 1 6in (30 – 40cm) within row and 18 – 30in...

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... helix of the third cluster of CHCs is part of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the ... rather than functional role Role of hydrophobic contacts in serine hydroxymethyltransferase In the present study, the importance of the third hydrophobic cluster as a structural determinant of ... Y55¢ interacts with the phosphate moiety of PLP; E57¢ is crucial in the binding of the l -serine hydroxyl group [15] and in the catalysis of the hydroxymethyltransferase reaction [16]; and Y65¢ interacts...

Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

... of glycogen in the intact liver in vivo Second, during infusion of [1-1 3C ]glucose, label incorporation was observed not only into the C1 of glycogen but also the C6 , which can only occur by label ... a mechanism can lead to increases in labeling of glycogen C6 even in the presence of decreased activity of the indirect pathway, provided that the increase in glycolytic ﬂux exceeded the decreased ... (A) The stack plot of 1 3C spectra acquired over 7.6 h after beginning at t ¼ (right scale), the infusion of [1-1 3C ]glucose 1 3C- label incorporation into hepatic glycogen was detected in the glycogen...

Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx

... monophosphate kinases L Wang supply of nucleoside monophosphates may regulate the synthesis of nucleoside di- and triphosphates In Mollicutes, other enzymes exist that are capable of synthesizing nucleoside ... puriﬁcation of Ureaplasma nucleoside monophosphate kinases Primers used in PCR ampliﬁcation of Ureaplasma nucleoside monophosphate kinases were designed according to the DNA sequence of the respective ... volume of 20 lL The reaction was initiated by the addition the enzyme (100 ngÆreaction)1 for the determination of NTP synthesis rates and 0.5–1 ngÆreaction)1 for the determination of NDP synthesis...

Báo cáo khoa học: Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism pdf

... responsible for the decrease of thyroid hormone biosynthesis in primary cultures in the presence of insulin In addition, our data suggest that insulin stimulates cell division, in bovine thyroid cultures, ... signiﬁcant increase in concentration of the peroxidase inhibitor by the action of insulin, during 48 h, in thyroid primary cultures with 0.1% fetal bovine serum, totally depleted of the hormone, 48 ... results, without discarding the anti-apoptotic effect of insulin [24], demonstrate that both insulin and the peroxidase inhibitor, in the absence of TSH, stimulate cell growth of thyroid cultures Conversely,...

RESEARCH, DESIGN AND FABRICATION OF DIGITAL INFORMATION TRANSIMITER WORKING IN THE VHF BAND

... Vietnam, information transceiver system working VHF bands have a lot of important applications Therefore, the study of information transceiver systems in the band VHF to understand the structure, the ... buildings can be a problem in urban areas 1.3 Thesis objectives and structure In this thesis,I will clarify the roles and the need of a information digital transmitter in VHF band Study the function ... These characteristics include the following + Changes in the slope of the analog input signal determine the step-size changes of the digital output signal + The feedback loop is adaptive to the...

báo cáo hóa học: " Primary Sjögren''''s Syndrome: health experiences and predictors of health quality among patients in the United States" potx

... Validation of the PROFAD-SSI among Sjogren's syndrome patients in the United States The data provided represent the statistical validation of the PROFAD-SSI among Sjogren's syndrome patients in the United ... interpret[9,10] The present study was designed to address these gaps in the PSS literature and to provide a systematic investigation of the health experiences of a large cohort of PSS patients in the United ... functioning among PSS patients in every domain of the SF-36, and increased utilization of health care services including medications, hospitalization rates, provider visits and out- of pocket...

Xem thêm

Từ khóa: what is the role of proton magnetic resonance spectroscopy in the diagnosis and follow up of brain neoplasms sources distribution and toxicity of polycyclic aromatic hydrocarbons pahs in particulate matter the role of multiple sequence repeat motifs in the assembly of multi protein complexes definitions and categories of drugs to be stocked in the pharmacy the role of continuous positive airway pressure in the management of decompensated heart failure complicated by acute pulmonary edema epidemiology and classification of non hodgkins lymphoma nhl in the elderly life and eight of their branches probably occurred in the lca life and five of their branches probably occurred in the lca the action of drugs on single neurones in the brain ece activity may be one of many regulators of a amp 946 accumulation in the brain ncam120 140 and 180 are expressed at equivalent levels in the brain calcium absorption colonic fermentation and role of galactose hh yoo js lee hs kwon tk shin ty kim sh 2011 elsholtzia ciliata inhibits mast cell mediated allergic inflammation role of calcium p38 mitogen activated protein kinase and nuclear factor κb exp biol med 236 9 pp 1070 7 creation collection processing distribution and use of information definition and role of activation energy in a chemical reaction Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thống Báo cáo quy trình mua hàng CT CP Công Nghệ NPV Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt nam đề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giải Biện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọ Phối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọ Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ long Phát hiện xâm nhập dựa trên thuật toán k means Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùng Nghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000 Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tin Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khí BT Tieng anh 6 UNIT 2 Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui ro Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ