Investigations into the chemopreventive potential of stilbenes, indolinones and isoindigos synthesis and mode of action studies

... INVESTIGATIONS INTO THE CHEMOPREVENTIVE POTENTIAL OF STILBENES, INDOLINONES AND ISOINDIGOS: SYNTHESIS AND MODE OF ACTION STUDIES ZHANG WEI (B.Sc., SOOCHOW UNIVERSITY) A THESIS SUBMITTED FOR THE ... of the chemical shifts of the aromatic protons of ring B (in particular H-2' and H-6') provided a useful means of assigning the Z/E configuration of the compound The 1H and 13 C NMR spectra of ... product The synthesis of the 3-substituted indolin-2-ones (1-48) was carried out in the presence of the base piperidine as catalyst Under these conditions, the enol tautomer of oxindole forms the...

báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... then a further pathway to the potential modulating properties of these peculiar organelles If tumor exosomes are such a powerful instrument of environmental shaping, then getting rid of them should ... differentiation In fact, we have more recently observed that the presence of tumor exosomes during monocyte differentiation into DC skews the whole process toward the generation of aberrant cells expressing ... hypothesized that this pathway may contribute to the in vivo moulding of immune as well as other cancer-related host responses More recent studies have then reported that the detrimental effect of...

Investigations into the transport properties of angiotensin peptides

... SECTION TWO AIM OF THESIS i AIM OF THESIS The aim of this thesis is to obtain a better understanding of the transport properties of the angiotensin peptide DAA-I across the intestinal epithelium DAA-I ... modelling of the angiotensin peptides 4.3.2 69 79 Determination of physicochemical and size parameters of the angiotensin peptides 88 iv 4.3.3 Structure- transport correlations of angiotensin peptides ... Number: AM02-02131 Asian Association of Schools of Pharmacy (AASP), 2004 Transport Properties of Angiotensin Peptides Peptides Transport of angiotensin peptides across the Caco-2 monolayer (Accepted...

Báo cáo khoa học: Investigations into the ability of an oblique a-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide pot

... contribute to the susceptibility of E coli model membranes to the action of AP1 An important determinant of the susceptibility of membranes to a-AMPs is the packing characteristics of the individual ... hypothesis of Tytler et al [48], it may be that insertion of the inverted wedge shape formed by the AP1 a-helix into membranes of E coli leads to the formation of nonbilayer structures and thereby ... FEBS S R Dennison et al Antimicrobial properties of an anionic a-helical peptide Fig A pressurearea isotherm for an AP1 monolayer The peptide was spread from chloroform on to a Tris HCl buffer...

Báo cáo Y học: Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction ppt

... anchoring by E coli PBPs 4, 5, and 6b (Eur J Biochem 269 ) 5827 Fig Helical wheel representations of protein segments The C-terminal sequences of PBP4, PBP5, PBP6 and PBP6b, and the primary sequence of ... 0 .65 0.23 Ó FEBS 2002 Membrane anchoring by E coli PBPs 4, 5, and 6b (Eur J Biochem 269 ) 5823 The peptides P4 and P5 (Table 1) were supplied by PEPSYN, University of Liverpool, UK, produced by ... phase ﬂuidity and a decrease in liquid crystalline phase ﬂuidity (C) Here, we analyzed the C-terminal sequences of PBP4, PBP5, PBP6 and PBP6b to identify candidates with the potential to form oblique...

Evaluation of the chemotherapeutic and chemopreventive potential of triterpenoids from poria cocos

... MMP-9 expression Together, the findings presented in this PhD study had expanded on the current understanding of the anticancer potential of triterpenoids from Poria cocos xi LIST OF TABLES Table ... further reinforce the importance of natural products as sources of agents with anticancer potential Chapter 1.2 Triterpenoids from Poria cocos 1.2.1 Triterpenoids The triterpenoids are a large and ... potential of these triterpenoids, several lines of evidence have suggested that triterpenoids from Poria cocos may have cancer therapeutic potential Li et al investigated the cytotoxicity and DNA...

Investigations into the effects of traditional chinese medicinal herbs used in the treatment of human breast cancer

... clinical trial designs very challenging 1.2 Herbs used in TCM for cancer treatment In TCM, cancer is viewed as the result of imbalance of the whole body-mind network by taking into account the ... anti-inflammatory, anti-infectious and diuretic effects The combination of these herbs might explain their efficacy in improving the quality -of- life (QOL) in cancer patients (Read, 1977) 10 The effects ... evaluate the effectiveness of the combined use of Western and traditional medicine in the treatment of disease states like breast cancer 1.4 Rationale and purpose of this study Breast carcinoma...

Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

... 20–564), and the model is composed of residues 25–540 The overall structure of the model of IPU and the mutated residues in this study are shown in Fig To elucidate the mechanism of the substrate ... in the negatively numbered subsites, and the substrate preference of the negatively numbered subsites of IPU also resembles that of GH family 49 dextranases Materials and methods Host strains and ... of Glc +2 of the a-(1ﬁ4)-linked glucose units of pullulan (Fig 4A) IPU is an anomer-inverting enzyme Comparison of the active sites of the model of IPU and Dex49A The active site structures of...

Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt

... with the sequences of 1CEV and 1RLA and pasted into the structural alignment The alignment was then corrected by hand Since the sequences of the two arginases and agmatinase greately differ in the ... that the environment of tryptophan residues is essentially conserved in the mutant enzyme On the other hand, the absence of major differences in the CD spectra of the wild-type and D153N agmatinases ... metal ligands are not substantially affected by the mutation, as revealed by the conservation of the whole topology of the active site, would explain the essentially unaltered interaction of the D153N...

Báo cáo khoa học: A novel metallocarboxypeptidase-like enzyme from the marine annelid Sabellastarte magniﬁca – a step into the invertebrate world of proteases pdf

... annulata, Budonosoma granulifera, Cassiopea xamachana, Condylactys gigantea, Gorgonia ventalina, Lebrunia danae, Palythoa caribaeorum, Physalia physalis, Plexaura homomalla, Stichodactyla helianthus ... Phyla Cnidaria, Annelida, Mollusca, Echinodermata, Arthropoda and Chordata, amongst others, collected on the coasts of Havana, Cuba The 4876 Fig S magniﬁca Phylum Annelida, Class Polychaeta, Subclass ... Subclass Palpata, Order Canalipalpata, Suborder Sabellida, Family Sabellidae, Genus Sabellastarte [14] The ‘tentacle crown’ and the ‘body’ parts of the animal are clearly visible study has been based...

Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using ﬂuorescence spectroscopy pptx

... Brownian rotation of the ﬂuorescent nucleotide Fig Binding of Ant-dATP to AC (d) and AC–CaM (m) The degree of binding of the ligand was calculated from the value of the amplitude of the long lifetime, ... new activation mechanism Recently, the resolution of the 3D structure of the AC exotoxin of B anthracis and of its complex with CaM led to the proposal of a different CaM-dependent regulatory mechanism, ... all of the residues of the catalytic mechanism are present in the neighborhood of the catalytic site, but they are not ordered correctly in the exotoxin alone CaM binding folds parts of the regulatory...

No DREAMers Left Behind - The Economic Potential of DREAM Act Beneficiaries potx

... No DREAMers Left Behind The Economic Potential of DREAM Act Beneficiaries Raul Hinojosa Ojeda and Paule Cruz Takash with Gerardo Castillo, ... considered non-biased and produced with high professional standards The MPI’s report, DREAM vs Reality: An Analysis of Potential DREAM Act Beneficiaries, explores the obstacles that potential DREAM Act ... called No DREAMers Left Behind, ” we analyze the income that would be generated in the same 40-year period if the entire group of 2.1 million potential beneficiaries could successfully meet the education...

Báo cáo khoa học: Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190 pot

... refolding [26 ,27 ] Consequently, we hypothesized that modulation of the catalytic potential of the catalytic triad might be accessible through point site mutations of the proximal residue, Tyr190, ... (Eqn 2) [27 ] On the basis of the Ping Pong mechanism, the acetylation rate (k2) of NAT2 by the acetyl donor is independent of the transacetylation rate (k4) of the arylamine substrate Because the ... of active mutants of hamster NAT2 at His107 and Asp 122 after refolding suggested that these two catalytic residues have both catalytic and structural roles [26 ,27 ] With the exception of the catalytic...

Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx

... Jolla, CA, USA) with pET2 8a( +)-wild-type Ec DosH as a template and using the following respective 5¢-sense primers: 5¢-gatga gtcgggagACCcagctggagaaaaaag-3¢, 5¢-gatgagtcgggagTTTcag ctggagaaaaaag-3¢, ... auto-oxidation [5], whereas Ala and Asn substitutions at Asp40, an amino-acid residue that interacts via two water molecules with the proximal ligand His77, markedly increased the rate of auto-oxidation ... kinetics of CO binding was not markedly in uenced by the mutation of Leu99 or Leu115 These ﬁndings are in contrast with the fact that mutations at the Met95 residue, the distal axial ligand in the...

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