Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 5

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays

... analytes, containing 1, and 10 nM of icariin, icaritin and desmethylicaritin; 5, 30 and 60 nM of icariside I and 71 icariside II, respectively and internal standard in pooled rat sera, were placed ... using lipofectamine Sixteen hours posttransfection, the cells were washed, trypsinized and split at ratio of in 10, in 100 and in 1000 into selective cell culture media containing 100 μg/mL of hygromycin ... fetal bovine serum and 10 μg/mL insulin in a humidified atmosphere of 5% carbon dioxide in air at 37°C 53 2.3 ERα and ERβ cell- based bioassays 2.3.1 Establishment of ERα and ERβ stable cells (from...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 2

... bioactivity of androgenic compounds in sera (Fig 26 F) 120 Figure 26 : Estrogenicity in serum following ingestion of estradiol valerate or Epimedium decoction Following baseline blood sampling (—▲—), ... (1.00-1. 12) 0.043 E2V 21 16 1.67 (1.58-1.77) ...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 4

... that of genistein and kaempferol (Maggiolini et al., 20 04; Leung et al., 20 04) The presence of serum reduced ERα binding of quercetin in MCF-7 cells, with relative binding affinities for genistein, ... effectiveness in sera of the decoction when administered orally Ingestion of a defined Epimedium decoction resulted in a 6% increase in ERα AUC effect over baseline in the subjects The increase in Epimedium ... group on ring B to interact with Glu-353 and Arg3 94 and another similar interaction involving the hydroxyl group on ring A with His-5 24 In contrast, for the case of icaritin, the interaction with...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 5

... ascertain whether the ingestion of estrogenic prenylflavonoids from Epimedium for the purpose of maintaining bone health can increase risk of ERα-positive breast cancer Interestingly, icaritin, ... and sulfatase Non-linear pharmacokinetics and prolonged effects for up to 72 h following administration of a single dose of Epimedium extract were also observed Coupled processes of enteric and ... endometrium and breast, the next step is to develop and validate a panel of such cell- based bioassays Even within the same cell line, differences exist in the ability of different compounds to induce estrogen- regulated...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 6

... P., Lee, L., Li, J and Yong, E.L 2009 Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract ... Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects Eur J Clin Nutr 61 (4):472-7 Klinge, C.M 2000 Estrogen receptor interaction ... of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats Mol Pharm 4 (6) : 865 -72 Mueller, S.O 2002 Overview of in vitro tools to assess the estrogenic and...

A numerical study of elastica using constrained optimization methods

... and spatial elastica Planar elastica comprise three mostly encountered cases: pin-pin elastica, clamp-pin elastica, and clamp-clamp elastica When both ends of elastica are clamped, and the system ... Diagram of D − λ1 / Pcr (spatial clamp-clamp elastica) ………… … 82 Figure 4.38 Diagram of D − λ3 / Pcr (spatial clamp-clamp elastica) …………….…82 Figure 4.39 Diagram of D − Strain energy (spatial clamp-clamp ... Superimposition of all configurations of clamp-pin elastica ……….69 Figure 4.24 Geometry of planar clamp-clamp elastica. ……………………… … 70 Figure 4.25 Diagram of D − P / Pcr (clamp-clamp elastica) ……………………….70...

REGIONAL HEALTH PRIORITIES AND OPPORITIES: ''''EVIDENCE FOR ACTION IN THE CHANGING GLOBAL FINANCIAL SITUATION'''' ppt

... Rwanda Ministry of Health Rwanda Ministry East African Community Kigali Health Institute Rwanda Biomedical Center RWANDA: GEOgrAPHY AND TOUrISM main theme: Regional health priorities and opportunities: ... ‘Evidence for Action in the Changing Global Financial Situation’ Opening session on translation of research into policy and practice (a session of politicians, scientists, policy makers, health ... Societies and Federations (25th to 27th March 2013) Conference Proceedings: The proceedings of the conference and other health research articles will be compiled and published in the 1st Issue of the...

Dynamics of Sewage Spillage and Storm Water Pollution on Lake Victoria Basin- A Case Study of Kisumu Municipality pdf

... Paper 2000–2 International Centre for Research in Agroforestry and Kenya Ministry of Agriculture and Rural Development, Soil and Water Conservation Branch, National Soil and Water Conservation ... Moorhouse, T and MaNabb, T The abundance and Distribution of Water Hyacinth in Lake Victoria and Kagera River Basin, 1989 – 2001 Report ,2002 Joseph L Awange and Obiero Ongángá Lake VictoriaEcology, ... address sewage and storm water challenges especially in urban centers in developing nations as they lack adequate financial technical and managerial resources to successfully protect lake land water...

Báo cáo khoa học: "The study of tree fine root distribution and dynamics using a combined trench and observation window method" doc

... various observation methods and techniques are discussed of A trench and an observation window tested in order to estimate root distribution and growth in a natural oak-birch stand in central ... must also be cautious in generalizing on sampling technique (small sampling not random, no replicates, etc.) an area basis, was not intended for that area, as our The statistical data showed that ... coordinate the number and species : the basis of For quality of roots was thus obtained This presentation allowed mathematical calculations to be 11 made on the variable &dquo ;root density per square...

Báo cáo y học: "Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors" pps

... observed in of patients with RCC in this study confirmed the efficacy of everolimus in Chinese patients with RCC, consistent with experience from the larger phase III study in RCC [11] At the time of ... al.: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors Journal of Hematology & Oncology 2011 4:3 ... phase I study was recommended by the China State Food and Drug Administration to evaluate PK, safety, and antitumor activity of oral everolimus and 10 mg/day in Chinese patients with advanced solid...

Study of microwave assisted magnetization dynamics in magnetic films and structures

... understanding of the mechanism of microwaveassisted magnetization reversal and study the influence of shape and patterning effects on the reversal process, and (b) To suggest improvements in current ... regardless of material parameters and geometry It demonstrates its versatility by detecting an indirect signature of domain nucleation and switching in large area thin films of CoFeB In patterned ... techniques offer the twin benefits of writing capability on high anisotropy materials and smaller sized grains (< nm) while maintaining thermal stability Heat -assisted magnetic recording (HAMR) and microwave- assisted...

The dynamics of literary representation and interpretation in a multilingual environment a study of selected malaysian and singaporean novels in english

... THE DYNAMICS OF LITERARY REPRESENTATION AND INTERPRETATION IN A MULTILINGUAL ENVIRONMENT: A STUDY OF SELECTED MALAYSIAN AND SINGAPORE NOVELS IN ENGLISH ROSALY JOSEPH PUTHUCHEARY (M .A, in English ... language and mother tongues as the second The National Language (Bahasa Kebangsaan) which is standard Malay became gradually the medium of instruction in all schools in Malaysia after 1976 Although English ... was slow and somewhat erratic, it is not surprising that the main lingua franca among the non -English educated remained Bazaar Malay, while among the English educated, a new lingua franca, Singapore-Malayan...

Ant functional group succession dynamics correlates with the age of vegetation succession data analysis of worldwide studies and a case study of a secondary tropical rain forest in singapore

... FOREST OF SINGAPORE Introduction The main island of Singapore is located off the southern tip of the Malay Peninsula and most of the island consisted of tropical lowland rain forest for much of the ... demonstrated this pattern of functional group succession by conducting a study of the ant community within a secondary tropical rain forest in Singapore Using the mathematical models, the ages of ... New Caledonia Barro Colorado Island, Panama Barro Colorado Island, Panama Atherton Tablelands, Australia Kununurra, Australia Vicosa, Brazil Mkomazi Game Reserve, Tanzania Popondetta, Papua New...

Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

... history of diabetes and higher body mass indexes During the five years of follow-up, 1 02 (15 .2% ) patients in the normoglycaemia group and 66 (18.3%) patients in the hyperglycaemia group died There ... inclusion in the study We excluded 21 1 patients who refused to participate in the study, 20 3 patients due to terminal illness, and another 29 patients who were receiving corticosteroid treatment Of the ... RF: Inflammatory status and insulin resistance Curr Opin Clin Nutr Metab Care 20 02, 5:551-559 14 Marette A: Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings...

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