Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

... REGULATION OF NHE1…………… 11 0 3B .1 DOWN -REGULATION OF NHE1 BY H2O2 11 0 3B .1. 1 Identification of crucial region in the promoter of NHE1 11 0 3B .1. 2 H2O2 down-regulates 0 .15 kb proximal NHE1 promoter ... signaling 21 1.3.4 Regulation of estrogen receptors 23 1. 3.5 Estrogen and estrogen receptors in human breast cancer 27 v 1. 4 THE SODIUM HYDROGEN EXCHANGER 29 1. 4 .1 pH regulation ... turnover 16 1. 3 ESTROGEN RECEPTOR 17 1. 3 .1 Estrogen and estrogen receptors: Introduction 17 1. 3.2 Estrogen receptor and genomic signaling 20 1. 3.3 Membrane and cytoplasmic...

Dual activation of estrogen receptor a and aryl hydrocarbon receptor by the prenylflavone, icaritin restrict breast cancer cell growth and destabilize estrogen receptor a protein

... Despite the availability of therapies targeting estrogen and growth factor signaling pathways, the incidence and mortality of breast cancers have not decline at the same rate as other major causes of ... 36 1.8 Icaritin and cancer cell proliferation 1.8.1 Icaritin and cancer cell proliferation Herba Epimedii is officially listed in China as an herb that prevents the growth of cancer and has been ... therapy in postmenopausal hormone therapy and recurrence of breast cancer Table shows the risk of breast cancer recurrence in breast cancer survivors after hormone replacement therapy [Figure adapted...

Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx

... replication by drugs that block eIF5A modification Inhibition of HIV replication by drugs that block eIF5A modification A Hypusination of eIF5A (gray) occurs in two steps: the transfer, catalyzed by DHS, ... DHS, of an aminobutyl moiety (blue) from spermidine onto the side chain of eIF5A lysine-50, yielding deoxyhypusine (Dhp); and its subsequent hydroxylation, catalyzed by DOHH, yielding hypusine ... substrate, deoxyhypusyleIF5A Inhibition of gene expression from HIV-1 molecular clones To explore the mechanism whereby CPX and DEF inhibit HIV gene expression, we first examined the specificity of their...

Regulation of na+ h+ exchanger 1 (NHE 1) gene expression by mild oxidative stress

... Regulation of activity and expression of NHE 1 54 1. 4.4 A 1. 4.4 B 1. 5 Regulation of NHE -1 activity 54 Transcriptional regulation of NHE -1 expression .58 AIM OF STUDY 61 ... response repression of NHE -1 expression .11 1 Figure 13 : Thiol oxidizing agent diamide mimicked the effect of H2O2 in the downregulation of NHE -1 gene expression 11 3 Figure 14 : ME inhibited ... inhibition of NHE -1 gene expression by thiol-oxidant diamide 11 9 Figure 18 : Caspases and 10 are not activated by H2O2 in L 61. 1 cells 12 1 Figure 19 : H2O2 induced activation of caspases...

Retrovirology Commentary BioMed Central Open Access Inhibition of HIV-1 gene expression by pptx

... Sam68ΔC Understanding regulation of Understanding regulation of HIV-1 gene expression by Sam68ΔC (A) Following transcription, HIV-1 RNA undergoes alternative splicing to generate over 40 mRNAs that ... next page) Page of (page number not for citation purposes) Retrovirology 2009, 6:22 http://www .retrovirology. com/content/6/1/22 Figure (see previous page) HIV-1 gene expression by Sam68ΔC Understanding ... spliced HIV-1 RNAs that all use the Nxf1 export pathway (Fig 1A), selective repression of Nef expression may require a different mechanism than that outlined by Marsh et al Inhibition of Nef expression...

Tài liệu Báo cáo khoa học: Redox regulation of dimerization of the receptor proteintyrosine phosphatases RPTPa, LAR, RPTPl and CD45 pdf

... investigated dimerization and the role of oxidation in dimerization of a panel of four different RPTPs We compared four RPTPs from different subtypes, i.e RPTPa, RPTPl, CD45 and LAR We found that the ... native RPTPa, or to the presence of low amounts of monomers Nevertheless, there was a clear difference in accessibility between oxidized and reduced LAR, RPTPl and CD45 chimeras, as was the case ... conditions The ectodomains of both monomers in the dimer are required for this effect, suggesting that the epitope tag of one monomer is masked by the ectodomain of the other monomer in the dimer, and...

Báo cáo y học: "Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo" ppt

... Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo Clinical Sarcoma Research 2011 1:5 Submit your ... investigated the effect of ESR -signaling modulation on the proliferation of chondrosarcoma cells in vitro by measuring the effect of steroids and clinical drugs inhibiting estrogen- signaling We evaluated ... effect of estrogen or inhibitors of estrogen signaling on cell proliferation and viability in vitro using central chondrosarcoma cell lines and primary cultures Despite the previously presented and...

Differential global effects of selective estrogen receptor modulators on estrogen receptor binding and transcriptional regulation

... Imhof and McDonnell 1996) Transcriptional controls from histones Another significant transcriptional control is the discovery of histones and their functions to control the accessibility of chromatin ... as one of the factors for predicting and diagnosing breast cancer (Ali and Coombes 2000) Estrogen receptor belongs to the family of steroid receptor and is activated by the hormone estrogen Estrogen ... understand the mechanisms of regulation by estrogen receptor and how it is modulated by SERMS This is mainly achieved by eliciting and examining the modulation of the global ER binding sites and...

Báo cáo y học: " mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer" pdf

... hsa-miR-769-5p RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors Figure RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors The figure ... significantly higher inhibitory activity in ER- cancer, strongly indicating that the differential regulatory effects of miRNAs can not be explained by miRNA expression differences between ER+ and ER- ... MN (b) Figure expression of miRNA processing genes between ER+ and ER- breast cancer samples Differential Differential expression of miRNA processing genes between ER+ and ER- breast cancer samples...

Báo cáo y học: "Discovery of estrogen receptor α target genes and response elements in breast tumor cells" ppsx

... activity and expression profiles of target genes A number of genes, including those for trefoil factor 1/ pS2, cathepsin D, cyclin D1, c-Myc and progesterone receptor, are positively regulated by ... factor binding elements occur very frequently in the genome, finding an ERE, AP-1 or Sp1 site only in ER-responsive genes is highly unlikely Instead, we asked whether the probability of finding an ... harvested by interactions We suggest the relevance of many of these estrogen- response genes to breast tumor biology by showing significant similarities between estrogen- induced expression profiles in...

Tài liệu REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL doc

... relevance) THE EUROPEAN PARLIAMENT AND THE COUNCIL OF THE EUROPEAN UNION, Having regard to the Treaty on the Functioning of the European Union, and in particular Article 114 thereof, Having regard to the ... either by the European Parliament or the Council within a period of two months of notification of that act to the European Parliament and the Council or if, before the expiry of that period, the ... 45/2001 of the European Parliament and of the Council of 18 December 2000 on the protection of individuals with regard to the processing of personal data by the EU institutions and bodies and on the...

Báo cáo khoa học: The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are inﬂuenced by the C-terminal 42 amino acids doc

... lacked the last 42 amino acids Figure 2A and Table show that the ATPase activity of NBD2-DC was greater than that of SUR2B but similar to that of NBD2A, favoring the idea that the last 42 amino acids ... than those for the NBDs of SUR2A [22] SUR2A and SUR2B differ only in their last 42 amino acids, which not form part of the catalytic site Thus, these amino acids may interact with the NBDs to modulate ... (site and site 2) that comprise the Walker A and Walker B motifs of one NBD and the linker domain of the other In the absence of Mg2+, there is little difference in ATP block of Kir6.2 ⁄ SUR2A and...

REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on the Cohesion Fund and repealing Council Regulation (EC) No 1084/2006 pot

... and urban transport EN EN 2011/0274 (COD) Proposal for a REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on the Cohesion Fund and repealing Council Regulation (EC) No 1084/2006 THE EUROPEAN ... general provisions on the European Regional Development Fund, the European Social Fund and the Cohesion Fund and repealing Regulation (EC) No 1083/20068 [Common Provisions Regulation - CPR] establishes ... surveillance of the Stability and Growth Pact EN Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee, the Committee of the Regions and the...

Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf

... role of acylCoA synthetases and thioesterases in the regulation of steroidogenesis by using triacsin C and NDGA on ACTHstimulated steroid synthesis in Y1 cells For this purpose, ACTH-stimulated Y1 ... Neuman, I., Finkielstein, C.F & Podesta, E.J (1997) Involvement of arachidonic acid and the lipoxygenase pathway in mediating luteinizing hormone-induced testosterone synthesis in rat Leydig cells Endocr ... obligatory role of the protein in steroidogenesis, we detected the protein and its mRNA in all steroidogenic tissues including placenta and brain [32] Inhibition of ACTH release and steroid synthesis...

Guide to U.S. Regulation of Genetically Modified Food and Agricultural Biotechnology Products

... characteristics of the genetically modified food to those of comparable food; • A discussion of “available data” on the allergenic and toxic potential of the modified food; • A description of any applications ... and its products could be the subject of regulatory review This report is intended to provide a general descriptive guide to the current set of U.S laws and regulations under which products of ... into a final product, such as corn that is modified to resist insect pests and also is processed into food products The federal statutes that are used to regulate the products of agricultural biotechnology...

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