Some problems in protein protein interaction network growth processes
Some problems in protein protein interaction network growth processes
... without investigation into the links between biological molecules, in particular, protein- protein interactions (PPI) Protein- protein interactions are physical contacts between two or more proteins ... nodes are proteins and edges are protein- protein interactions Usually, a PPI network represents a collection of protein- protein interaction data in an organism For example, by incorporating all ... phenotype, we need to investigate protein- protein interaction (PPI), metabolic and gene regulation networks in addition to studying individual genes and their proteins [9, 71] Since PPI networks are available...
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Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
... number of protein protein interactions ⁄ number of complexes (inter ⁄ comp.), while the STRING search results are presented as number of protein protein interactions (inter.) only Proteins are ... contained regions of intrinsic disorder One example of an ordered hub, calmodulin, makes use of a flexible hinge to facilitate binding diversity Each of these classes and their roles in protein protein ... important roles in the binding interactions of these hub proteins The xeroderma pigmentosum group A protein (XPA) represents an interesting example of a partially disordered hub protein Xeroderma...
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Báo cáo y học: "A human functional protein interaction network and its application to cancer data analysis" potx
... procedures to construct this FI network (Figure 1), and apply this network to the study of glioblastoma multiforme (GBM) and other cancer types by expanding a human curated GBM pathway using our ... of the proteins in the hand-curated GBM pathway In this way we were able to extend the hand-curated pathway from 73 proteins and 187 interactions to 181 proteins and 768 interactions A total of ... data analysis We have applied this system to the analysis of two genome-wide GBM data sets and data sets from other cancer types and revealed common network patterns in cancer related genes and...
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Báo cáo y học: "Consistent dissection of the protein interaction network by combining global and local metrics" ppt
... robust in terms of discovering protein interaction modules in protein interaction networks than either the global or local algorithm by application to the large yeast protein interaction network Genome ... Ultimately, the global metric in the GN algorithm behaves differently from the local metric in the ECC algorithm In this paper, we propose to resolve this conflict by combining the global and local ... best in terms of maximal modularity In particular, on the noisy original data, the maximal modularity Q value by the BCD algorithm is significantly higher than the Q values by the other two algorithms,...
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Báo cáo y học: "A scale of functional divergence for yeast duplicated genes revealed from analysis of the protein-protein interaction network" doc
... (Table 2) The evolution of cellular function: from the scale of functional divergence to the evolutionary fates of the duplicated genes Our study was driven by the idea that investigating the cellular ... proposal of a functional scale of divergence for yeast duplicated genes As our work makes use of functional gene annotations and interaction lists, it is important to examine how the quality of these ... conservation/ divergence of the yeast duplicated genes, we analyzed available textual information relative to the actual functions of the 460 pairs of paralogs from the WGD For this purpose, we used the...
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Báo cáo y học: "What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae" pot
... cutoffs, most of the FYI party hubs also qualify as party hubs in the DIP network and the FYI date hubs as DIP date hubs (Figure 2) The resulting number of proteins in each category in the respective ... static hubs (party hubs) and dynamic hubs (date hubs) [14] The party hubs are found in static complexes where they interact with most of their partners at the same time, while the date hubs bind their ... duplicability of hub proteins is similar to that of other proteins However, very few static hub (party hub) paralogs originate from relatively recent duplications We hypothesize that the number of retained...
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Automated linear motif discovery from protein interaction network
... neither motifs can 22 Protein A Motif Discovery Algorithms Figure The One-to-Many (OTM) approach to finding motif from interaction data Dotted arrow denotes interaction between two sequences Motifs ... directly for motifs Specifically, not many motif discovery algorithms (in fact, only one algorithm to the best of our knowledge) have been designed to mine motifs directly from protein- protein interaction ... short linear sequence patterns, termed linear sequence motifs, to guide experimental and functional studies of novel proteins Note that linear sequence motifs are different from structural motifs...
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Báo cáo khoa học: "Some Problems in the Mechanical Translation of German" pdf
... excludes the possibility of it being nominative, then the relative pronoun may be taken to be the subject of the clause This applies to about half of all the instances where the function of the relative ... fact only in subordinate clauses and in the part of a main clause after the finite verb Since in a main clause, unless it is interrogative or imperative, the finite verb must normally be the second ... scheme * The P in parentheses indicates that if a prepositional phrase occurs before the subject in the German, it is to be retained in the same position in the English translation Mechanical Translation...
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Tài liệu Báo cáo Y học: Prediction of protein–protein interaction sites in heterocomplexes with neural networks ppt
... Predicting protein–protein interaction sites (Eur J Biochem 269) 1357 More recently, methods were devised for predicting residues involved in protein interaction sites in the absence of any structural ... (1997) Analysis of protein–protein interaction sites using surface patches J Mol Biol 272, 121–132 14 Jones, S & Thornton, J.M (1997) Prediction of protein–protein interaction sites using surface ... in many protein folding and traffic processes in the cell The main component of the system is DnaK, a two-domain protein with a C-terminal domain responsible for the binding of unfolded hydrophobic...
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Báo cáo hóa học: " Research Article Extraction of Protein Interaction Data: A Comparative Analysis of Methods in Use" potx
... completeness of information obtained from abstracts in comparison to the full-length articles as a measure of reliability of abstracts as sources of protein interaction data METHODS Selection of articles ... (proprietary protein interactions maps database from Jubilant Biosys Ltd.) was used IMaps is a manually curated database with more than 200 000 protein- protein, proteinRNA, protein- small molecule, and protein- DNA ... wrongly annotated as serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member and PI 4-phosphate 5-kinase as prolactininduced protein intensive Therefore, manual...
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Báo cáo y học: "Modular organization in the reductive evolution of protein-protein interaction networks" pps
... Therefore, rather than fragmenting the network, the removal of nodes and links in the Buchnera network maintains the global topology of the network, preserving the main interaction backbone The prefer- ... within the interaction network are important in the reductive process Accordingly, the importance of the roles of the proteins must be taken into consideration when discussing the effect of the ... in these interactions Therefore, we calculated the total number of interactions per pair of proteins in STRING and, accordingly, the number of interactions per pair that would be expected within...
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Báo cáo y học: "How biologically relevant are interaction-based modules in protein networks" ppsx
... shown that by combining protein- protein data and phylogenetic information it is possible to systematically describe biologically relevant modules in protein networks which partially correlate ... reviews Proteins Proteins Proteins Module Proteins comment Species Module Proteins Poyatos and Hurst R93.3 (b) Interaction matrix Proteins Proteins (a) Genome Biology 2004, R93.4 Genome Biology 2004, ... probability of finding lethal genes in the set of proteins without human homolog belonging to the significant cores We compared this with the probability of finding lethal genes in those yeast proteins...
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Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx
... hypothetical protein- protein interaction network Each sphere represents a protein and the connecting lines represent protein- protein interactions Within an interaction network, smaller local interaction ... and independently fusing these domains with candidate interacting proteins [21,22] Constructs encoding these fusion proteins are transformed into yeast cells; if the two candidate proteins interact ... can now be inferred from clustering within the HD protein- protein interaction network, a more directed research strategy can be used when investigating these proteins The recent study by Goehler...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXBT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ