Statistical significance assessment in computational systems biology
Statistical significance assessment in computational systems biology
... STATISTICAL SIGNIFICANCE ASSESSMENT IN COMPUTATIONAL SYSTEMS BIOLOGY LI JUNTAO (Master of Science, Beijing Normal University, China ) A THESIS SUBMITTED FOR THE ... (scanning level, pre/postwashing), location effect (chip, coverslip, washing), dye effect (dye, unequal mixing of mixtures, labeling, intensity), print pin effect, spot effect (amount of DNA in the ... = 0.7(indep.) input calibrated input π0 = 0.9(dep.fix) input calibrated π0 = 0.9(dep.random) Error 0.00 0.05 0.10 0.15 0.20 π0 = 0.9(indep.) calibrated input calibrated input calibrated input...
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Báo cáo y học: "Computational models in systems biology" pot
... system is used This is conceptually much simpler The future is likely to see many more mechanistically understood models of actual biological systems that rely on computational methods in systems ... Institute of Biochemistry, Martinsried, Germany) demonstrated the down-to-earth potential of Genome Biology 2008, 9:328 http://genomebiology.com/2008/9/12/328 Genome Biology 2008, models in systems ... in developing automated methods for determining the intracellular location of proteins tagged with green fluorescent protein Traditionally, this could only be done by expert microscopic examination...
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Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx
... describing systems biology applied to biochemistry in the years 2000–2010 employing the ten most commonly used software tools models, lindo (Lindo Systems Inc., Chicago, IL, USA; www.lindo.com) and ... found using the keyword systems biology actually reflect applications of systems biology approaches to biological systems resulting in new biological insights However, on the other hand, and by ... (see entry in Table 1), understanding the metabolism of tobacco grown on media containing different cytokines (see entry 176 in Table 1) and the investigation of substrate channeling in the urea...
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Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc
... identification and simulation A mathematical model was developed, representing central carbohydrate metabolism in leaves of A thaliana The model was based on the following system of ordinary differential ... in A thaliana A D B E C F Fig Maximum activities of enzymes in central carbohydrate metabolism during cold exposure (A C) Vmax values of three invertase isoforms: vInv, nInv and eInv (D) Vmax of ... (1999) Acclimation of Arabid¨ opsis leaves developing at low temperatures Increasing cytoplasmic volume accompanies increased activities of enzymes in the Calvin cycle and in the sucrose-biosynthesis...
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Tài liệu Báo cáo khoa học: "Generating statistical language models from interpretation grammars in dialogue systems" potx
... This adaptation includes the facility of generating Nuance recognition grammars from the interpretation grammar and the possibility of generating corpora from the grammars The interpretation grammar ... are considering basing our re-ranking on the information held in the dialogue information state, knowledge of what is going on in the graphical interface and on dialogue moves in the list that ... look at dialogue move specific statistical language models (DM-SLMs) by using GF to generate all utterances that are specific to certain dialogue moves from our interpretation grammar In this way...
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Báo cáo khoa học: Measuring enzyme activities under standardized in vivo-like conditions for systems biology pdf
... obtained in the in vivo-like assay medium, suggesting that the ‘optimized’ conditions are, in reality, not optimal for these enzymes A thorough analysis of the yeast kinetics of phosphofructokinase ... enzyme of interest should be investigated in the context of the in vivo-like medium Finally, in vivo, the enzymes are present at much higher concentrations than in typical enzyme assays, in which ... shown in Table The in vivo-like Vmax values were sufficient to support the maximal flux Discussion In order to support coordinated efforts to standardize experimental conditions for systems biology, ...
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Báo cáo khoa học: Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells potx
... hypothesis-driven science in the postgenomic era Bioessays 26, 99105 17 Kell DB (2005) Metabolomics, machine learning and modelling: towards an understanding of the language of cells Biochem Soc Trans 33, 520524 ... models and reality on one hand and between changes in the model that are invoked and its subsequent dynamic behaviour, leading to an understanding of how events at one level (e.g the enzymatic) can ... Metabolomics, modelling and machine learning systems D B Kell sciences, engineering, mathematics and computer science One solution, that we are adopting in the Manchester Interdisciplinary...
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Báo cáo toán học: " Modeling formalisms in Systems Biology" ppt
... types of agents, representing two different kinds of cells (or two kinds of molecules) can move freely and interact within the containing space; e) Interacting state machine: systems are represented ... unambiguously interpreted by different people Modeling Formalisms Many formalisms have been used to model biological systems, in part due to the diversity of phenomena that occur in living systems, ... understanding of cellular systems We describe the features required by an integrated framework for modeling, analyzing and simulating biological processes, and review several modeling formalisms...
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Báo cáo hóa học: " A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana" pdf
... this article as: Henkel et al.: A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:2 Abbreviations ... presented a kinetic modelling approach to simulate and analyse diurnal dynamics of carbohydrate metabolism in A thaliana Based on simulated fluxes in leaf cells, we could assign possible physiological ... supporting a crucial role in plant carbohydrate metabolism In addition, a prevailing role of hexokinase in regulating Scr cycling would explain why a strong reduction of invertase activity caused...
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Báo cáo sinh học: "Growth control of the eukaryote cell: a systems biology study in yeas" ppt
... paper online Additional data file contains additional figures Additional data file contains additional tables Additional data file contains the legends for the additional figures and tables Additional ... Feller A, Crabeel M, Pierard A: Control- mechanisms acting at the transcriptional and post-transcriptional levels are involved in the synthesis of the arginine pathway carbamoylphosphate synthase of ... in steady state at growth rates of both 0.1 and 0.2/hour, and as these data had been normalized and statistically analyzed in the same way, we were able to make a realistic determination of the...
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Báo cáo sinh học: "Multilevel regulation of growth rate in yeast revealed using systems biology" pptx
... role in growth- rate regulation increasing growth rates in all four nutrient-limiting conditions Transcripts that were up- and downregulated with growth rate were similar to those found in the ... a protein kinase that is important in the control of eukaryotic cell growth [19] Further emphasizing the importance of TOR in growth- rate control, the study found that 72.5% of growth- rate- regulated ... decrease in levels of glutamate Instead, there was a corresponding trend in the increase in the transcript and protein levels of the mitochondrial 2-oxoglutarate transporters, and an increase in protein...
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Báo cáo y học: "The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics" ppt
... phosphorylation in yeast Nature 2005, 438: 679-684 23 Yip KY, Yu H, Kim PM, Schultz M, Gerstein M: The tYNA platform for comparative interactomics: a web tool for managing, comparing and mining multiple ... proteins and in DNA binding for AR and hydrophilicity-sensitive proteins In addition, charge-sensitive proteins showed an enrichment in transferase activity and MlogP in transcriptional regulator ... We used two types of networks: protein-protein interactions and gene regulatory [21] (genetic interaction and phosphorylome [22] had too few nodes to determine significance) All topological statistics...
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báo cáo khoa học: " A systems biology model of the regulatory network in Populus leaves reveals interacting regulators and conserved regulation" potx
... repository of much of the Populus cDNA microarray data [10] and databases for the analysis of gene expression - and other - data [11] substantially facilitates the ability to perform systems biology ... between each pair of regulators (i.e the cross-term b12 in the case of two regulators) is plotted against the influence of each individual regulator (i.e b1 and b2 in the case of two regulators) In ... available gene function information and generalizes to new expression data in both Populus and Arabidopsis We identify the main regulators of primary processes in leaves, and show how some of these...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ