Suitability of insulin like growth factor 1 (IGF1) as a measure of relative growth rates in lingcod

... ARTICLE Suitability of Insulin- Like Growth Factor (IGF1) as a Measure of Relative Growth Rates in Lingcod Kelly S Andrews* and Brian R Beckman National Oceanic and Atmospheric Administration–Fisheries, ... body growth for lingcod Ophiodon elongatus using plasma insulin- like growth factor (IGF1) with the ultimate goal of measuring spatial differences in relative growth rates Insulin- like growth factor ... evaluate spatial variation in plasma IGF1 levels in lingcod among sites in the San Juan Islands archipelago Last, we compare the spatial patterns of traditional biological measurements of lingcod...

Tài liệu Báo cáo khoa học: Identiﬁcation of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc

... presence of four families of type II transmembrane serine proteinase [30] The matriptase subfamily constitutes three members (matriptase, matriptase and matriptase 3) It is conceivable that some of ... analyses of purified matriptase Soluble matriptase was purified from the conditioned medium of DLD-1 cells as described in the text The purified matriptase (approximately 200 ng of total proteins) was ... this study, we first identified the type II membranebound serine proteinase matriptase as a processing enzyme of IGFBP-rP1 ⁄ AGM Matriptase was initially FEBS Journal 273 (2006) 615–627 ª 2006 The...

Báo cáo khoa học: Identiﬁcation of the amniotic ﬂuid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms docx

... degradation of IGFBP-1 isoforms The y-axis shows the percentage of the ratio between the spot area of the degraded and that of the untreated protein measured using IMAGE J 1.37V software the presence of ... almost to the same extent as the unmodiﬁed protein and that the susceptibility to proteolytic degradation of the isoforms increased with the number of phosphates linked to the polypeptide chains The ... elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis Endocrinology 144, 3922–3933 Westwood M (1999) Role of insulin-like growth factor...

Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx

... high-af®nity binding proteins (IGFBPs) with 10 -fold higher af®nity than their binding to IGF receptors IGFBPs thereby in¯uence the availability of IGF to bind to IGF receptors [12 ] Over the past 14 years, ... analogue binding to highanity recombinant IGF1 R Binding of IGF- II (A), des- (1 6) -IGF- II (B) and Arg6 -IGF- II (C) to rhIGF1R measured by BIAcore analysis using concentrations of 25, 50, 10 0, 200 and ... af®nity binding of IGF- I, IGF- II and their analogues to rhIGF1R was measured by BIAcore analysis (Figs and 2), and relative binding af®nities were determined (Table 1) Arg3 -IGF- I, des- (1 3) -IGF- I,...

Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx

... Effects of inhibitor treatment (wortmannin and U0126) on insulin ⁄ IGF-1-induced phosphorylation of PI3K ⁄ Akt ⁄ mTOR-dependent signaling in C2C12 myotubes Fig S2 Complex formation of TSC1 and TSC2 ... versus control group (P < 0.05) Phosphorylation of Akt and S6K1 was induced within 10 min, and was maintained for at least 60 Altered distributions of TSC1 and TSC2 proteins were also detected on the ... indicated that Akt in uences mTOR signaling by regulation of the protein complex of tuberous sclerosis complex (TSC)1 ⁄ TSC2 [9–12] The TSC1 ⁄ TSC2 protein complex is a heterodimer composed of...

Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf

... hyperinsulinemic hypoglycaemia Chang Gung Med J 2008, 31: 107 -11 doi :10 .11 86 /14 79-5876-8 -11 7 Cite this article as: Pantaleo et al.: The emerging role of insulin-like growth factor receptor (IGF1r) ... WT: Insulin-like Pantaleo et al Journal of Translational Medicine 2 010 , 8 :11 7 http://www.translational-medicine.com/content/8 /1/ 117 Page of growth factors and insulin-like growth factor- binding ... FJ: Insulin-like growth factor- I receptor/ human epidermal growth factor receptor Pantaleo et al Journal of Translational Medicine 2 010 , 8 :11 7 http://www.translational-medicine.com/content/8 /1/ 117 ...

Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc

... H: Cytokines and bone loss in a 5-year longitudinal study — hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin- 1receptor antagonist: the Danish ... Baylink DJ, af Ekenstam E, Lindh E, Mohan S, Ljunghall S: Circulating levels of insulin-like growth factor- I and -II, and IGF- binding protein-3 in inflammation and after parathyroid hormone infusion ... correlation with IL-6 and sIL-6R [27] In this study, serum levels of sIL-6R decreased significantly in the HRT group Furthermore, the change in E2 in serum was inversely, though modestly, correlated with...

Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt

... (IGF) -1 to IGF -binding proteins, on 12 5I-labeledinsulinbinding NBI- 317 72, a small-molecule inhibitor like growth factor (IGF) -1 to IGF -binding proteins, on 12 5I-labeled IGF -1 binding to human osteoarthritic ... – 0 .1 10 10 mary cultured factor (IGF) -1 to IGF -binding proteins (IGFBPs), in insulin-like of NBI- 317 72, a small-molecule inhibitor of the binding of priActivitygrowth rabbit chondrocytes lin-like ... IGF- 1of insulin-like growth factor (IGF) -1 to IGF -binding proteins (IGFBPs), in primary cultured of NBI- 317 72, a small-molecule inhibitor of the binding tured human osteoarthritic chondrocytes incubated...

báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc

... this article as: Jones et al.: Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring InsulinLike Growth Factor-1 in a Preclinical Model of Human Breast Cancer ... conditions in the University of Maryland, Baltimore animal facility and maintained in accordance with institutional guidelines approved by the University of Maryland, Baltimore Animal Care and Use ... a pattern of progressive adenocarcinoma with similar genetic changes and pathophysiology as seen in human breast cancers associated with BRCA1-mutations [11,12] Additionally, as in human BRCA1-associated...

Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis" pps

... cytokine- inducible SH2-containing protein, suppressors of cytokine signaling- 2 and suppressors of cytokine signaling3 Bars represent the mean expression of mRNA of cytokine- inducible SH2-containing ... activation of cytokines We therefore measured the serum concentrations of a pleiotropic cytokine (IL-6) and an anti-inflammatory (IL-10) cytokine and the expression of mRNA of SOCS proteins, of IGF-I ... in the activity of the immune system In this regard, the effect of sepsis and the influence of nutrition on tissue protein metabolism and on the functioning of the growth hormone (GH)–insulin-like...

Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx

... before and after cultivation for days Values are the means and standard errors of the mean (n = 6) other tissues also secrete this peptide at a lower level [20–22] The predominant secretion of 8K-BLP ... than to those of bombyxin and insulin, which are of the order of 100 pm [23,24] The very high titer of 8K-BLP may be due to a remarkably high level of gene expression in the fat body and to the ... Among these, bombyxins, a family of peptides produced by the brain of the silkmoth Bombyx mori, were the ﬁrst to be demonstrated to have structural homology to vertebrate insulins [7,8] Bombyxin-II,...

Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc

... skeletal myotube hypertrophy FEBS Journal 273 (2006) 3709–37 21 ª 2006 The Authors Journal compilation ª 2006 FEBS 3 719 Insulin-like growth factor signaling 14 15 16 17 18 19 20 21 22 23 24 25 A ... that Neu2 expression is dependent on AKT activation during IGF -1- induced differentiation of myoblasts Neu2 expression is strictly dependent on IGF -1 signaling To establish whether Neu2 expression ... (19 95) Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myoﬁber hypertrophy in transgenic mice J Biol Chem 270, 12 109 12 116 ` Musaro A, McCullagh...

báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx

... (IGF1R): Insulin-like Growth Factor- 1 receptor; (IGFBP-3): Insulin-like Growth Factor Binding Protein-3; (IGFBP-4): Insulin-like Growth Factor Binding; Protein-4; (MAPK): Mitogen-activated protein kinase; ... role of secreting IGFBPs in melanoma However, data not support the clinical utility of measuring levels of IGFBP-3 and -4 in sera of melanoma patients Abbreviations (IGF): Insulin-like Growth Factor; ... Cohen P: The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action Endocrinol Metab Clin North Am 1996, 25(3):591-614 Rajaram S, Baylink DJ,...

báo cáo hóa học: " Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide" ppt

... Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide Sook-Eun Park1,2,4, ... response to activation of the innate immune system [1-3] Exposure of volunteers to a low dose of endotoxin induces depressed mood that correlated with cytokine expression, independent of sickness behaviors ... proven to be reliable indices of depression-like behaviors Blocking the anti-depressant activity of exogenous IGF-I with JB1, which prevents IGF-1R receptor activation, shows that IGF-1R activation...

Nghiên cứu tạo dòng, biểu hiện và thu nhận hIGF 1 (human insulin like growth factor 1) từ escherichia coli

... 1. 1 Nhân tố tăng trƣởng hIGF- 1 1. 1 .1 Giới thiệu 1. 1.2 Đặc điểm gene mã hóa cấu trúc phân tử protein hIGF- 1 1. 1.3 Đặc điểm hoạt động hIGF- 1 1. 1.4 Chức hIGF- 1 ... hành nghiên cứu sản xuất protein hIGF- 1 công nghệ DNA tái tổ hợp Trong khuôn khổ chương trình nghiên cứu, luận văn thực nhằm: Nghiên cứu tạo dòng, biểu thu nhận hIGF- 1 (human insulin- like growth ... 1. 1.5 Các hướng ứng dụng hIGF- 1 1. 1.5 .1 Điều trị bệnh IGFD 1. 1.5.2 Điều trị số bệnh khác 1. 1.5.3 Ứng dụng khác hIGF- 1 10 1. 1.6 Tình hình nghiên cứu sản...

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