Linear and branched chitosan oligomers as delivery systems for pDNA and siRNA in vitro and in vivo

... well-defined, low Mw chitosans (chitosan oligomers) as delivery systems for nucleic acids (pDNA and siRNA) in vitro and after lung administration in vivo In addition, the concept of receptor targeting ... uptake and efficient endosomal release Besides their efficiency as pDNA delivery systems, lipid-based formulations were reported as efficient delivery systems for siRNA in vitro and in vivo [105-107] ... conventional chitosans in vitro and in vivo (Paper I) Enhance the transfection efficiency of chitosan oligomer-based pDNA formulations in vitro and after lung administration in vivo by coupling a targeting...

Beverages as Delivery Systems for Nutraceuticals

... served as cold or hot beverages Homemade chicken soup has always been perceived to be healthful.28 Before the concept of nutraceuticals was introduced, chicken soup competed with wine and yogurt for ... can be formulated to produce nutraceutical drinks is unlimited Sport beverages have a special purpose and for that reason may not be thought of as Þrst-line nutraceutical beverages Sport beverages ... be a prebiotic for use in beverages 132 No single carbohydrate or potential source of dietary Þber has generated as much interest in the past to years as FOS Commonly referred to as a prebiotic,126...

Drug delivery systems for antiangiogenesis and anticancer activities

... nanoparticulated combinatorial drug delivery system for simultaneous antiangiogenesis and anticancer activities could improve the therapeutic outcome The nanoparticle formulations described in this ... ligands for antitumor and antiangiogenesis activity (79-81) 1.3.2 Vascular targeted nanoparticle drug delivery Nanoparticulate delivery system surface modified with integrin targeting ligand ... targeted nanocapsule with sequential drug delivery for temporal antiendothelial and anticancer activities 44 3.1 Introduction 45 III 3.2 Materials and methods 46 3.2.1...

The evaluation of bioactive polycaprolactone scaffolds as protein delivery systems for bone engineering applications

... serve as effective protein delivery systems for the repair 28 of bone tissue The merit of the work was that the PCL-based scaffolds could serve not only as a template for bone growth but also as ... fabrication The evaluation of these novel scaffolds forms the basis of this thesis It is hypothesized that PCL-TCP scaffolds would surpass the first generation PCL scaffolds as a graft material and protein ... evaluate the efficacy of the scaffolds as delivery systems for multiple growth factors, platelet-rich plasma (PRP) was used The buffers sufficed as important determinants of the release profiles...

Báo cáo khoa học: Efﬁcient and targeted delivery of siRNA in vivo pdf

... development of effective in vivo delivery systems is pivotal in overcoming the challenges in achieving efficient and targeted siRNA delivery in vivo Major hurdles in siRNA delivery in vivo and various ... progress in achieving efficient and targeted siRNA delivery in vivo, particularly by overcoming multiscale hurdles using novel siRNA carriers, is discussed Challenges in RNAi in vivo Design and in vivo ... FEBS 4815 In vivo siRNA delivery M S Shim and Y J Kwon Fig Interdisciplinary approaches to achieving efficient and targeted RNAi in vivo by overcoming multiscale barriers in systemic siRNA delivery...

Improvement of different vaccine delivery systems for cancer therapy pptx

... the surface of PLGA NPs [62] These polymers have been designated as feasible candidates for drug delivery systems, anti -cancer agents and vaccine immunotherapy For example, DNA vaccine delivery ... doi:10.1186/1476-4598-10-3 Cite this article as: Bolhassani et al.: Improvement of different vaccine delivery systems for cancer therapy Molecular Cancer 2011 10:3 ... consisting of two doses of DNA with EP [10] Actually, this approach might be very attractive because it would eliminate the need for two different types of vaccine For example, the use of a DNA vaccine...

Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx

... thinking Because of the synthesis impairment, acetylcholine is decreased in the neurons in the Alzheimer disease brain, leading to the incapability of learning, memory, and thinking Providing ... there are great possibilities for them to be used in the construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems ... surge in the number of publications in this interesting field Apart from their uses in the cellular imaging with diagnostic effects in nanomedicine [4,5], CNTs are promising drug carriers in the target...

Báo cáo y học: " Membrane diffusion- and capillary blood volume measurements are not useful as screening tools for pulmonary arterial hypertension in systemic sclerosis: a case control study" pptx

... in a decrease in capillary flow and thus a decrease in Vc This will result in a reduction in surface area available for gas exchange, and therefore in a decrease of Dm [25] Secondly, parenchymal ... capacity of the alveolar capillary membrane as percentage of predicted (Vc%/Dm%) and the pulmonary vascular resistance (PVR) and the mean pulmonary artery pressure (mPpa) in patients with systemic ... parenchymal and vascular destruction in areas of Dm and Vc in SScPAH+ compared with SScPAHDm% in SScPAH+ was significantly lower as compared with SScPAH- This difference could not be ascribed to factors...

THE STUDY OF NOVEL LIGHT DELIVERY SYSTEMS FOR HEAT ASSISTED MAGNETIC RECORDING

... densities up to 3.5 Tb/in2 [43] 1.7 Heat- Assisted Magnetic Recording The concept of heat- assisted magnetic recording (HAMR) is similar to the concept of magneto-optical recording proposed by Katayama ... by thermal fluctuations but is prevented by an energy 11 barrier given by the product of the magneto crystalline energy and the volume of the magnetic grain The magnetic orientation of a magnetic ... to enhance magnetic recording 1.4 Conventional Recording Schemes 1.4.1 Longitudinal Magnetic Recording (LMR) In LMR, the information is written along the surface of the magnetic media The media...

Development of live bacterial delivery systems for presentation of dengue EDIII to the mucosal immune system 2

... 70 2. 2 .2. 3.1.3 Coomassie Blue staining 71 2. 2 .2. 3.1.4 Electroblotting 71 2. 2 .2. 3.1.5 Immunoblotting 71 2. 2 .2. 3 .2 Flow cytometry 72 2 .2. 2.4 Animal work 73 2. 2 .2. 4.1 Mouse strains 73 2. 2 .2. 4 .2 Intranasal ... Bacterial strains 67 2. 2 .2. 1 .2 Culture conditions 68 2. 2 .2. 2 Bacterial transformation 69 2. 2 .2. 2.1 Preparation of electrocompetent cells 69 2. 2 .2. 2 .2 Electroporation 69 2. 2 .2. 2.3 Double homologous ... response 21 1.5 LIVE BACTERIAL VECTORS FOR ANTIGEN DELIVERY 22 1.5.1 Rationale for using a live bacterial vector 22 1.5 .2 Attenuated pathogens 24 1.5 .2. 1 B pertussis as a live vector for nasal delivery...

Báo cáo sinh học: " The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World" pdf

... study was limited in its scope, the results indicate that WNV strain IS-98-ST1 is suitable as viral model for West Nile encephalitis in the Old World The Israeli strain IS-98-ST1 that caused the ... the fact that an Israeli WNV strain was introduced in New York City in 1999 [4] The murine model of WNV-associated encephalitis has been widely used to address the viral pathogenesis[5] Strains ... 1998, as well as WNV strains present in North America does contrast with the low pathogenicity of most ancestral strains of WNV[18,19] In conclusion, the Israeli strain IS-98-ST1 of WNV provides...

Báo cáo y học: "Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes" ppsx

... the data collection phase and the start of assembly and analysis The end of this phase will be marked clearly on the snake genomics website [21], as will milestones of data analysis and release ... 100:659-674 Page of doi:10.1186/gb-2011-12-7-406 Cite this article as: Castoe TA, et al.: Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations ... expansion of snake genomics Research incorporating snakes as model systems is becoming increasingly popular and diverse in its breadth of topics The availability of the python genome and associated resources...

Báo cáo y học: "Spinal cord stimulation as a treatment for refractory neuropathic pain in tethered cord syndrome: a case report ppsx

... this article as: Moens et al.: Spinal cord stimulation as a treatment for refractory neuropathic pain in tethered cord syndrome: a case report Journal of Medical Case Reports 2010 4:74 Submit your ... electrical nerve stimulation (TENS) partly diminished her pain Subsequently, a spinal cord stimulator (SCS) was surgically placed when our patient was under epidural anesthesia An epidural catheter ... of SCS in patients with TCS The implantation of a spinal cord stimulator in a patient with TCS as an effective treatment for refractory chronic neuropathic pain has not been described Page of...

Báo cáo y học: " Assessment of disease-severity scoring systems for patients with sepsis in general internal medicine departments" pdf

... curves for overall in- hospital mortality of the examined scoring systems MEDS, mortality in emergency medicine sepsis score; MEW, modified early warning; REMS, rapid emergency medicine score; ROC, ... general internal medicine departments Previous studies investigating scoring systems in septic patients were largely confined to ICU settings [8-12], whereas today the majority of septic patients ... prediction models for patients with sepsis admitted to general internal medicine departments, for all of the examined time points The scoring systems evaluated in the present study are simple and...

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