... expression of EGR-1, Snail and SP-1 in HepG2 HepG2 cells were untreated (con) or treated with 50 nM TPA for 0.5, 1, 2, and h (A and C) Real-time RT/PCR (A) and western blot (C) of EGR-1, SP-1 and Snail ... interaction of EGR-1 with Snail or SP-1 with TPA-responsive element of the p15INK4b promoter, and also protein–protein association of EGR-1 with Snail or SP-1 Thus, it is intriguing to examine whether ... that SP-1 (together with EGR-1) may bind on the overlapping EGR-1/ SP-1 region rather than on the adjacent single SP-1 was much higher Interestingly, simultaneous binding of EGR-1 and SP-1 to adjacent...