... transcription of an array of inflammatory genes, theirdirect regulation of MMP transcription is just beginning tobe elucidated. In the remainder of this review, we addresshow these pathway-specific ... arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factorsMatthew P Vincenti1and Constance E Brinckerhoff1,21Department of Medicine, Dartmouth ... col-lagenase] and MMP-13) have the unique ability to cleave the triple helix of collagen, thereby allowing the chains tounwind; the chains then become susceptible to furtherdegradation by other MMPs....