... for each of these mechanisms with the experimental results,these authors suggested a reaction mechanism inclu-ding both intra- and intermolecular activation of the zymogen by the action of the ... route of intramolecular activation of the zymogen into the active enzyme, E, and one or morepeptides represented by W [route (a), Scheme 3][12,22,25–27] and a route of autocatalytic activation of zymogen ... Introduction. Japan Scientific Soci-eties Press, Tokyo.27 Kageyama T & Takahashi K (1987) Activation mechan-ism of monkey and porcine pepsinogens A. One-step and stepwise activation pathways and their...