... or more without FFP results in dilutional coagulopathy, diffuse microvascular bleeding and increased mortality [40,41] Current guidelines for FFP in massive bleeding The principles of managing massive ... to 1 year FFP contains all of the clotting factors, fibrinogen (400 to 900 mg/unit), plasma proteins (particularly albumin), electrolytes, physiological anticoagulants (protein C, protein S, ... exhaustion of clotting elements and hyperfibrinolysis [50,51] While coagulopathy is common and critically important in traumatic brain injury, the controversial existing evidence suggests it may not differ...