... inhibitor of apoptosis dependent on the inhibition of activation of caspases, and also as an inducer of apoptosis,dependent on the activation of caspases [23,65]. However,the mode of action of Zn ... inthe time courses of induction of apoptosis (Fig. 3A) andproteolysis of PARP (Fig. 3B) by Py/Zn. Induction of apoptosis and activation of caspases were observed at 6 h of treatment. Moreover, ... execution of apoptosis[26]. We therefore examined the involvement of caspases inthe apoptosis induced by Py/Zn. PARP is a substrate of caspases, and proteolysis of PARP is an index of activationof...