... cell lines A possible strategy for the maintenance of intracellular heme level Yongzhao Zhang1, Kazumichi Furuyama1, Kiriko Kaneko1, Yuanying Ding1, Kazuhiro Ogawa2,*,Miki Yoshizawa1, ... required. In summary, the present study has suggested that the reduced expression of HO-2 protein may contrib-ute to the maintenance of intracellular heme level in certain human cell types under hypoxia. Experimental ... adaptation to hypoxia in certain cell types, which may contrib-ute to the maintenance of the intracellular heme level. AbbreviationsHO, heme oxygenase; HRE, hypoxia response element; MARE, Maf...