... signifi-cantly inhibited at nanomolar concentrations of RWJ 67657, and mRNA expression was also decreased, by nearly 50% at 10 nM. Inhibition of p38 MAPK activity leadsto reduced TNF-α mRNA expression ... biosynthesis. Nat Cell Biol 1999, 1:94-97.21. Bhattacharyya A, Pathak S, Datta S, Chattopadhyay S, Basu J,Kundu M: Mitogen-activated protein kinases and nuclear fac-tor-kappaB regulate Helicobacter pylori-mediated ... undercontrol of the p38 MAPK route. Inhibition of the p38 MAPKroute may inhibit production not only of TNF-α, but also of otherinflammatory mediators produced by macrophages, and indirectly of inflammatory...