THE INFLUENCE OF THE KU80 CARBOXY-TERMINUS ON ACTIVATION OF THE DNA-DEPENDENT PROTEIN KINASE AND DNA REPAIR IS DEPENDENT ON THE STRUCTURE OF DNA COFACTORS Derek S
... this
is the first report in which glycosylation of a TGF-b
superfamily ligand is essential for the versatility in
receptor binding.
Results and Discussion
Structure of human BMP-6
Structures of ... building using quanta2006 software (Accelrys Inc.,
Table 3. Processing and refinement statistics. Statistical analyses for the highest-resolution shell are shown in parentheses....
... levels of all other viral proteins. This suggests a
role for VP30 in replication or transcription.
The self-interaction of NP is the basis for the formation of
the helical nucleocapsid of MARV. ... function of NP in RNA synthesis.
Discussion
Coiled coil motifs are versatile domains that mediate the
interaction of proteins [16]. The central feature of coiled
coil mo...
... function of NP in RNA synthesis.
Discussion
Coiled coil motifs are versatile domains that mediate the
interaction of proteins [16]. The central feature of coiled
coil motifs is the presence of repeats ... intra- and intermolecular binding,
is a prerequisite for NP to perform its multiple tasks in
RNA synthesis and nucleocapsid morphogenesis. This
concept is supported b...
... response was confined to the tissues is of
interest as the aim of these models is to mimic the human
asthmatic condition, in which a significant portion of
reactivity of the lungs is localised ... Further
investigation is needed in order to understand the mech-
anisms that are influencing the site of responsiveness.
Typically, most human studies measure MCh respo...
... as multinucleated cells. It is pos-
sible that these tissue characteristics are responsible for
the prolonged presence of the message to Hsp65 in the
muscle tissue. However, there is no satisfactory ... suggesting the absence of inflammatory response in
these tissues (manuscript in preparation, Deison Soares
personal communication).
To assure that the plasmid rescued from di...
... of the
peptide. The origin of this structural orientation in Me
2
SO is
also the strong electrostatic interactions of the side c hain of
Arg78 with the side chains of Asp81 and G lu82 [this is
consistent ... Me
2
SO, are possibly due to
electrostatic interactions promoted in this solvent ( see
discussion below). A comparison of the chemical-shift data
of the...
... puta-
tive Pro-Glu-Ser-Thr site of proteolysis and several putative phosphoryla-
tion sites. In this study, we analysed CNBP phosphorylation by embryonic
kinases and its consequences on CNBP biochemical ... phosphorylated on Ser
⁄
Thr residues
In silico analysis showed that CNBP amino acid
sequences possess putative phosphorylation sites
mainly on Ser ⁄ Thr residues (Fig. 1). To c...
... France).
Statistical analysis
Using the nonparametric Kolmogorov–Smirnov test and
the Levene test, it was established that the distribution of
data obtained with different clones was normal. Student s
t-test ... he
QuickChange Site-directed Mutagenesis Kit (Stratagene)
was used to switch serines 73 and 138 and threonine 153 of
the HIP/PAP protein for alanines. Oligonucleo...
... expression
of HSP90 in the two rat tissues are similar to those
present in these cell models [27], we propose that the
occurrence of conditions which favour the formation
and stabilization of proteolytically ... 4B,D). The involve-
ment of calpain in these digestion processes was dem-
onstrated by the protective effect on both HSP90
and NOS degradation of the admin...
... citation purposes)
compensated for by one or more of the acquired substitu-
tions. We also did not observe restoration of the disulfide
bond by means of a first site reversion at position 418.
This ... and the
CXCR4 coreceptor for HIV-1
LAI
in relation to the positions
of the mutations and reversions in our viruses is given in
fig. 4A. Soluble CD4 (sCD4) was used to a...