Báo cáo y học: "Annotations for all by all - the BioSapiens network" pot

... of Systems Biology,Technical University of Denmark, DK-2800 Lyngby, Denmark; EskoUkkonen, Helsinki Institute for Information Technology, Helsinki Univer-sity of Technology and University of ... France.AAcckknnoowwlleeddggeemmeennttss The BioSapiens project is funded by the European Commission within itsFP6 Programme, under the thematic area ‘Life sciences, genomics andbiotechnology for health’, contract number LSHG-CT-200 3-5 03265.RReeffeerreenncceess1. ... (CERTH), Thermi Road,Thessaloniki, Greece; Anne-Lise Veuthey, Swiss Institute of Bioinformat-ics, rue Michel Servet, CH-1211 Geneva, Switzerland; Søren Brunak,Center for Biological Sequence Analysis,...

Báo cáo y học: " Screening for personality disorder with the Standardised Assessment of Personality: Abbreviated Scale (SAPAS): further evidence of concurrent validity" docx

... appen-dix disorders for further study) [8], and the SAPAS mayhave greater salience for some specific areas of personal-ity pathology The aim of the present study was to examine the con-vergent ... explained the rationale of the study.Subjects gave consent to participate in the study noearlier than 24 hours after being informed of the pur-pose of the study by the research technician. The sub-jects ... genetic risk mar-kers for ADHD [16]. For the present sample, the inter-nal consistency alpha was 0.84 for attention deficitsymptoms and 0.74 for hyperactivity symptoms. The Psychiatric Research...

Báo cáo y học: "Corticosteroids for sepsis: registry versus Cochrane systematic review" pot

... was strongly dependent on the dose of cortico steroids (P=0.02) - the lower the better - and the dura tion of treatment (P = 0.01) - the longer the better.  en, subgroup analysis based ... a strong heterogeneity across the studies (I2 = 53% by random-eff ects model), which was mainly explained by diff erences in treatment strategies. Indeed, the meta-regression using dose ... considered only in patients who are poorly responsive to fl uids and vaso pressors [6].Why should we be cautious in drawing conclusions from the PROGRESS registry?As highlighted by the authors,...

Báo cáo y học: "Rheumatoid arthritis and smoking: putting the pieces together" pot

... effects: there was anincreased risk for anti-CCP-positive RA in heavy smokers withhomozygote SE alleles [67].In the study of the Leiden Early Arthritis Clinic, the HLA-DRB1*0401, HLA-DRB1*0404, ... components rather than the TNFantagonism alone, evoked by nicotine, may therefore be the main susceptibility factors of disease development. Tosupport this hypothesis, in both types of inflammatory boweldisease ... not for citation purposes)more susceptible for degradation by metalloproteases. Inprimary biliary cirrhosis, celiac disease or systemic lupuserythematosus, antibodies against self-enzymes...

Báo cáo y học: " Unfashionable crop species flourish in the 21st century" potx

... revitalized in the US by the fact that the National Science Foundation (NSF) hasfunded creation of EST libraries for gene discovery and the physical mapping of these ESTs using aneuploid and dele-tion ... Approximately 4,485 ESTsthat had been physically mapped into bins along wheat chro-mosomes were compared using the NCBI BLASTN algo-rithm [11] to the first draft of the publicly available rice(Oryza ... in the evolution of wheat genomeorganization. The restricted opportunities for recombina-tion because of the self-pollinating nature of wheat rein-forces this phenomenon. A related paper by...

Báo cáo y học: " Role of clinical bioinformatics in the development network-based Biomarkers" docx

... parsimonious tree-grow method for haplotype inference (nPTG), identifying differentially expressed pathways via a mixed integer linear programming model (nMILPs), protein-RNA binding-site prediction ... Understanding the interaction between clinical informatics and bioinformatics is the first and critical step to discover and develop the new diagnostics and therapies for diseases. In order to optimally ... validated by the integration with clinical informatics which translates clinical descriptive information on complaints, sign, symptoms, biochemical analyses, imaging and therapies into the digital...

Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc

... A - (E )-3 -( 2-( thiophene-2-yl )-2 , 3- dihydrobenzo[b][1,4]thiazepin-4-yl)phenol (Figure 1) - was built using SYBYL® software(version 7.3, TRIPOS, St. Louis, MO) [28]. Subsequently, the overall ... significantly. These dynamics have already been inves-tigated extensively by MD simulations, suggesting that the high flexibility of the cleft isnecessary for enzyme activity. A comparison of the simulation ... Biochemistry 2005, 44:115 4-1 162.doi: 10.1186/174 2-4 68 2-7 -2 2Cite this article as: Ul-Haq et al., In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-ben-zothiazepine...

Báo cáo y học: "Making systems biology work in the 21st century" pot

... with increasing fre-quency in the literature - a search of PubMed on 3 January2005 produced 11 hits for the new year, more than for all the years before 1998, suggesting that the total of 316 ... systemsbiology over the next two years, investing £6 million in each.It was in the hope of answering them that a one-day meetingexploring the nature of systems biology and its potential wasorganized by ... interest and efforts, the applica-tion of systems theory in biology has not quite lived up toexpectation”. But what of systems biology today? Does it nowlook more likely to lead to the expected...

Báo cáo y học: "Getting a buzz out of the bee genome" pot

... mechanism. There is a sex-determining locuswith many alleles; heterozygous zygotes develop as females,hemizygous or homozygous zygotes develop as males [7].This hypothesis was confirmed for honey bees ... honey bees by Woyke [8]and the complementary sex determiner (csd) gene wascloned by Beye and colleagues in 2003 [9]. The product ofcsd is an RNA-binding protein and it may, like the Transformer ... for rise significantly in these brain regions, and these(now) foraging worker bees become positively phototactic.They then leave the darkness of the hive to become bona fideforagers [21]. In...

Báo cáo y học: "Molecular evolution of neuropeptides in the genus Drosophila'''' potx

... (1 0-1 7)* ( 6-1 1) Y Hugin pyrokinins (1) HUG-PK (8) Y IFamide IFamides (1) IFamide (12) Y Myoinhibiting peptide (MIP) MIPs (5) MIP-1 (9) Y MIP-2 (9) Y MIP-3 (13) Y MIP-4 (11) Y MIP-5 (10) Y Myosuppressin ... the efficacy of DTKs on DTKR - one of the two DTK receptorsknown - in HEK-293 cells [69]: DTK-1 > DTK-3 = DTK-6 >DTK-4 > DTK-5 > DTK-2. For CAPA-PVKs, the copy with the Genome Biology 2008, ... respec-tively). The respective maximum values for multiple copyfamilies are 0.748 for FMRFa-7, 0.601 for sulfakinin (SK )-0 ,0.267 for ETH-2, 0.208 for FMRFa-7, and 0.205 for CAPA-PVK-2. Yet,...

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